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The organoid: A research model for ovarian cancer
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establish...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333109/ https://www.ncbi.nlm.nih.gov/pubmed/35912056 http://dx.doi.org/10.4103/tcmj.tcmj_63_21 |
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author | Chang, Yu-Hsun Wu, Kun-Chi Harnod, Tomor Ding, Dah-Ching |
author_facet | Chang, Yu-Hsun Wu, Kun-Chi Harnod, Tomor Ding, Dah-Ching |
author_sort | Chang, Yu-Hsun |
collection | PubMed |
description | Epithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establishing a cell line is time-consuming, loss of genetic traits after long-term culture is a possibility, and investment is required in terms of animal care facilities. Therefore, better research models are required. Organoid technology was originally developed from colorectal cancer. Tumor organoid is a three-dimensional culture system and can help accurately recapture the tumor phenotype from the original tumor. Tumor organoid systems can overcome the above-mentioned shortcomings of the currently available research models. The organoid model can be used for culturing ovarian cancer subtypes, screening drugs, assessing genomes, and establishing biobanks. However, the currently available organoid models can only culture one type of cells, epithelial cells. Therefore, an organoid-on-a-chip device can be developed in the future to provide a microenvironment for cell–cell, cell–matrix, and cell–media interactions. Thus, organoid models can be used in ovarian cancer research and can generate a simulated in vivo system, enabling studies on the heterogeneity of ovarian cancer. |
format | Online Article Text |
id | pubmed-9333109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-93331092022-07-29 The organoid: A research model for ovarian cancer Chang, Yu-Hsun Wu, Kun-Chi Harnod, Tomor Ding, Dah-Ching Tzu Chi Med J Review Article Epithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establishing a cell line is time-consuming, loss of genetic traits after long-term culture is a possibility, and investment is required in terms of animal care facilities. Therefore, better research models are required. Organoid technology was originally developed from colorectal cancer. Tumor organoid is a three-dimensional culture system and can help accurately recapture the tumor phenotype from the original tumor. Tumor organoid systems can overcome the above-mentioned shortcomings of the currently available research models. The organoid model can be used for culturing ovarian cancer subtypes, screening drugs, assessing genomes, and establishing biobanks. However, the currently available organoid models can only culture one type of cells, epithelial cells. Therefore, an organoid-on-a-chip device can be developed in the future to provide a microenvironment for cell–cell, cell–matrix, and cell–media interactions. Thus, organoid models can be used in ovarian cancer research and can generate a simulated in vivo system, enabling studies on the heterogeneity of ovarian cancer. Wolters Kluwer - Medknow 2021-07-09 /pmc/articles/PMC9333109/ /pubmed/35912056 http://dx.doi.org/10.4103/tcmj.tcmj_63_21 Text en Copyright: © 2021 Tzu Chi Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Chang, Yu-Hsun Wu, Kun-Chi Harnod, Tomor Ding, Dah-Ching The organoid: A research model for ovarian cancer |
title | The organoid: A research model for ovarian cancer |
title_full | The organoid: A research model for ovarian cancer |
title_fullStr | The organoid: A research model for ovarian cancer |
title_full_unstemmed | The organoid: A research model for ovarian cancer |
title_short | The organoid: A research model for ovarian cancer |
title_sort | organoid: a research model for ovarian cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333109/ https://www.ncbi.nlm.nih.gov/pubmed/35912056 http://dx.doi.org/10.4103/tcmj.tcmj_63_21 |
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