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Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review

Monoclonal gammopathies of clinical significance (MGCS)-associated myopathy is a group of muscular MGCS-based rare manifestations. It mainly includes amyloid light chain (AL) amyloidosis and sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. When myopathy...

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Autores principales: Yu, Hongbin, He, Du, Zhang, Qing, Cao, Bei, Liu, Weiping, Wu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333131/
https://www.ncbi.nlm.nih.gov/pubmed/35912259
http://dx.doi.org/10.3389/fonc.2022.914379
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author Yu, Hongbin
He, Du
Zhang, Qing
Cao, Bei
Liu, Weiping
Wu, Yu
author_facet Yu, Hongbin
He, Du
Zhang, Qing
Cao, Bei
Liu, Weiping
Wu, Yu
author_sort Yu, Hongbin
collection PubMed
description Monoclonal gammopathies of clinical significance (MGCS)-associated myopathy is a group of muscular MGCS-based rare manifestations. It mainly includes amyloid light chain (AL) amyloidosis and sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. When myopathy manifests as the initial or sole clinical symptom, it can often be delayed or misdiagnosed as other myopathies. We report the case of a 60-year-old man who initially presented with fatigue and muscle weakness of the symmetric proximal lower limbs. Muscle biopsy did not reveal mononuclear cell infiltration, atrophy, necrosis, or positive Congo red staining results. The results of serum protein electrophoresis and immunofixation electrophoresis were negative. No specific diagnosis was established. After 1 year, the patient was diagnosed with AL amyloidosis after myocardial and fat pad biopsies were performed and myopathy was diagnosed as AL amyloidosis-associated myopathy after reassessment. The patient received CyBorD regime chemotherapy and achieved hematological and organ remission. Therefore, we reviewed the clinical and pathological manifestations of MGCS-associated myopathies. Based on published articles and the present case, we conclude that comprehensive screening for MGCS in unexplained myopathy is essential to avoid misdiagnosis or delayed diagnosis.
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spelling pubmed-93331312022-07-29 Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review Yu, Hongbin He, Du Zhang, Qing Cao, Bei Liu, Weiping Wu, Yu Front Oncol Oncology Monoclonal gammopathies of clinical significance (MGCS)-associated myopathy is a group of muscular MGCS-based rare manifestations. It mainly includes amyloid light chain (AL) amyloidosis and sporadic late-onset nemaline myopathy with monoclonal gammopathy of undetermined significance. When myopathy manifests as the initial or sole clinical symptom, it can often be delayed or misdiagnosed as other myopathies. We report the case of a 60-year-old man who initially presented with fatigue and muscle weakness of the symmetric proximal lower limbs. Muscle biopsy did not reveal mononuclear cell infiltration, atrophy, necrosis, or positive Congo red staining results. The results of serum protein electrophoresis and immunofixation electrophoresis were negative. No specific diagnosis was established. After 1 year, the patient was diagnosed with AL amyloidosis after myocardial and fat pad biopsies were performed and myopathy was diagnosed as AL amyloidosis-associated myopathy after reassessment. The patient received CyBorD regime chemotherapy and achieved hematological and organ remission. Therefore, we reviewed the clinical and pathological manifestations of MGCS-associated myopathies. Based on published articles and the present case, we conclude that comprehensive screening for MGCS in unexplained myopathy is essential to avoid misdiagnosis or delayed diagnosis. Frontiers Media S.A. 2022-07-14 /pmc/articles/PMC9333131/ /pubmed/35912259 http://dx.doi.org/10.3389/fonc.2022.914379 Text en Copyright © 2022 Yu, He, Zhang, Cao, Liu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yu, Hongbin
He, Du
Zhang, Qing
Cao, Bei
Liu, Weiping
Wu, Yu
Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title_full Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title_fullStr Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title_full_unstemmed Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title_short Case Report: Monoclonal Gammopathies of Clinical Significance-Associated Myopathy: A Case-Based Review
title_sort case report: monoclonal gammopathies of clinical significance-associated myopathy: a case-based review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333131/
https://www.ncbi.nlm.nih.gov/pubmed/35912259
http://dx.doi.org/10.3389/fonc.2022.914379
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