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The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study
This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes present...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333245/ https://www.ncbi.nlm.nih.gov/pubmed/35900984 http://dx.doi.org/10.1371/journal.pone.0271999 |
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author | Jeng, Yu-Ting Lai, Tso-Ting Lin, Chao-Wen Chen, Ta-Ching Hsieh, Yi-Ting Lin, Chang-Ping Ho, Tzyy-Chang Yang, Chung-May Yang, Chang-Hao |
author_facet | Jeng, Yu-Ting Lai, Tso-Ting Lin, Chao-Wen Chen, Ta-Ching Hsieh, Yi-Ting Lin, Chang-Ping Ho, Tzyy-Chang Yang, Chung-May Yang, Chang-Hao |
author_sort | Jeng, Yu-Ting |
collection | PubMed |
description | This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes presenting persistent or recurrent retinal fluid retention after 3 months of aflibercept loading injections. We defined the fluid tolerance ratio as the sum of fluid-tolerance duration divided by the total duration of retinal fluid observed throughout the follow-up period. Eyes were categorized into strict, intermediate, and relaxed group based on their fluid tolerance ratio (= 0, <30%, > = 30%, respectively). The mean total follow-up time was 556 days. The relaxed group required fewer injections than the strict group (4.92 vs 7.50 injections, P < 0.01) and presented a similar reduction in retinal thickness (-57.50 vs -71.65 μm, P = 0.83). Nonetheless, the two groups were similar in terms of final visual acuity (logarithm of the minimum angle of resolution 0.72 vs 0.70, P = 0.95) and visual gains (4.21 vs -1.12 letters, P = 0.56). These results indicate that in the setting of limited medical resources, a fluid-tolerant approach provides comparable gains in visual acuity. Reducing the number of injections may also improve adherence to therapy. |
format | Online Article Text |
id | pubmed-9333245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-93332452022-07-29 The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study Jeng, Yu-Ting Lai, Tso-Ting Lin, Chao-Wen Chen, Ta-Ching Hsieh, Yi-Ting Lin, Chang-Ping Ho, Tzyy-Chang Yang, Chung-May Yang, Chang-Hao PLoS One Research Article This study investigated the impact of retinal fluid tolerance on retinal thickness and visual acuity in patients with neovascular age-related macular degeneration after 18 months of treatment using intravitreal aflibercept. This retrospective study was based on the medical records of 90 eyes presenting persistent or recurrent retinal fluid retention after 3 months of aflibercept loading injections. We defined the fluid tolerance ratio as the sum of fluid-tolerance duration divided by the total duration of retinal fluid observed throughout the follow-up period. Eyes were categorized into strict, intermediate, and relaxed group based on their fluid tolerance ratio (= 0, <30%, > = 30%, respectively). The mean total follow-up time was 556 days. The relaxed group required fewer injections than the strict group (4.92 vs 7.50 injections, P < 0.01) and presented a similar reduction in retinal thickness (-57.50 vs -71.65 μm, P = 0.83). Nonetheless, the two groups were similar in terms of final visual acuity (logarithm of the minimum angle of resolution 0.72 vs 0.70, P = 0.95) and visual gains (4.21 vs -1.12 letters, P = 0.56). These results indicate that in the setting of limited medical resources, a fluid-tolerant approach provides comparable gains in visual acuity. Reducing the number of injections may also improve adherence to therapy. Public Library of Science 2022-07-28 /pmc/articles/PMC9333245/ /pubmed/35900984 http://dx.doi.org/10.1371/journal.pone.0271999 Text en © 2022 Jeng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Jeng, Yu-Ting Lai, Tso-Ting Lin, Chao-Wen Chen, Ta-Ching Hsieh, Yi-Ting Lin, Chang-Ping Ho, Tzyy-Chang Yang, Chung-May Yang, Chang-Hao The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title | The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title_full | The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title_fullStr | The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title_full_unstemmed | The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title_short | The impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: A real-world study |
title_sort | impact of retinal fluid tolerance on the outcomes of neovascular age-related macular degeneration treated using aflibercept: a real-world study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333245/ https://www.ncbi.nlm.nih.gov/pubmed/35900984 http://dx.doi.org/10.1371/journal.pone.0271999 |
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