Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption

This study aimed to determine the effects of zoledronic acid (ZOL) on OA in rats and explored the molecular mechanism of osteoclast activation in early OA. A knee OA rat model was designed by surgically destabilizing the medial meniscus (DMM). Seventy-two male rats were randomly assigned to Sham+pho...

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Detalles Bibliográficos
Autores principales: Ding, Dong, Wang, Limei, Yan, Jiangbo, Zhou, Yong, Feng, Gangning, Ma, Long, Yang, Yong, Pei, Xiuying, Jin, Qunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333271/
https://www.ncbi.nlm.nih.gov/pubmed/35900969
http://dx.doi.org/10.1371/journal.pone.0271485

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