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Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation

BACKGROUND: The metabolite succinate accumulates during cardiac ischemia. Within 5 minutes of reperfusion, succinate returns to baseline levels via both its release from cells and oxidation by mitochondrial complex II. The latter drives reactive oxygen species (ROS) generation and subsequent opening...

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Detalles Bibliográficos
Autores principales:	Milliken, Alexander S., Nadtochiy, Sergiy M., Brookes, Paul S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333399/ https://www.ncbi.nlm.nih.gov/pubmed/35766275 http://dx.doi.org/10.1161/JAHA.122.026135

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