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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

Emerging SARS-CoV-2 variants are creating major challenges in the ongoing COVID-19 pandemic. Being able to predict mutations that could arise in SARS-CoV-2 leading to increased transmissibility or immune evasion would be extremely valuable in development of broad-acting therapeutics and vaccines, an...

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Detalles Bibliográficos
Autores principales:	Bate, Neil, Savva, Christos G., Moody, Peter C. E., Brown, Edward A., Evans, Sian E., Ball, Jonathan K., Schwabe, John W. R., Sale, Julian E., Brindle, Nicholas P. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333441/ https://www.ncbi.nlm.nih.gov/pubmed/35849637 http://dx.doi.org/10.1371/journal.ppat.1010733

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