Association between TGF-β gene polymorphism and myopia: A systematic review and meta-analysis

INTRODUCTION: The present study was conducted to determine the association of transforming growth factor-beta (TGF-β) gene polymorphism and myopia. METHOD: Four hundred twelve articles were identified, of which 11 articles with 5213 participants in 4 countries were included in the final analysis. Review Manager software (RevMan, version 5.4) was used for data analysis. RESULT: Odds ratio (OR) value of TGF-β1 rs1800469 is 1.33 (95% confidence interval [CI] = 1.15–1.54) in the allelic model; in the dominant model is 1.76 (95% CI = 1.16–2.67); in homozygous model is 5.98 (95% CI = 4.31–8.06). OR value of TGF-β1 rs4803455 is 0.62 (95% CI = 0.43–0.88) in recessive model. TGF-β2 is not associated with myopia. Relevant study on TGF-β3 is scarce. CONCLUSION: Our systematic review and meta-analysis found that TGF-β1 rs4803455 and rs1800469 were correlated with myopia.