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Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients

We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients...

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Autores principales: Matsuo, Takuji, Tashiro, Haruko, Shirasaki, Ryosuke, Sumiyoshi, Ritsu, Yamamoto, Tadashi, Saito, Sumiko, Matsumoto, Kensuke, Ooi, Jun, Shirafuji, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333492/
https://www.ncbi.nlm.nih.gov/pubmed/35905283
http://dx.doi.org/10.1097/MD.0000000000029541
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author Matsuo, Takuji
Tashiro, Haruko
Shirasaki, Ryosuke
Sumiyoshi, Ritsu
Yamamoto, Tadashi
Saito, Sumiko
Matsumoto, Kensuke
Ooi, Jun
Shirafuji, Naoki
author_facet Matsuo, Takuji
Tashiro, Haruko
Shirasaki, Ryosuke
Sumiyoshi, Ritsu
Yamamoto, Tadashi
Saito, Sumiko
Matsumoto, Kensuke
Ooi, Jun
Shirafuji, Naoki
author_sort Matsuo, Takuji
collection PubMed
description We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables. Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test. These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL.
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spelling pubmed-93334922022-08-03 Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients Matsuo, Takuji Tashiro, Haruko Shirasaki, Ryosuke Sumiyoshi, Ritsu Yamamoto, Tadashi Saito, Sumiko Matsumoto, Kensuke Ooi, Jun Shirafuji, Naoki Medicine (Baltimore) Research Article We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables. Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test. These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL. Lippincott Williams & Wilkins 2022-07-29 /pmc/articles/PMC9333492/ /pubmed/35905283 http://dx.doi.org/10.1097/MD.0000000000029541 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Matsuo, Takuji
Tashiro, Haruko
Shirasaki, Ryosuke
Sumiyoshi, Ritsu
Yamamoto, Tadashi
Saito, Sumiko
Matsumoto, Kensuke
Ooi, Jun
Shirafuji, Naoki
Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title_full Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title_fullStr Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title_full_unstemmed Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title_short Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
title_sort serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333492/
https://www.ncbi.nlm.nih.gov/pubmed/35905283
http://dx.doi.org/10.1097/MD.0000000000029541
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