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Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients
We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333492/ https://www.ncbi.nlm.nih.gov/pubmed/35905283 http://dx.doi.org/10.1097/MD.0000000000029541 |
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author | Matsuo, Takuji Tashiro, Haruko Shirasaki, Ryosuke Sumiyoshi, Ritsu Yamamoto, Tadashi Saito, Sumiko Matsumoto, Kensuke Ooi, Jun Shirafuji, Naoki |
author_facet | Matsuo, Takuji Tashiro, Haruko Shirasaki, Ryosuke Sumiyoshi, Ritsu Yamamoto, Tadashi Saito, Sumiko Matsumoto, Kensuke Ooi, Jun Shirafuji, Naoki |
author_sort | Matsuo, Takuji |
collection | PubMed |
description | We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables. Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test. These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL. |
format | Online Article Text |
id | pubmed-9333492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93334922022-08-03 Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients Matsuo, Takuji Tashiro, Haruko Shirasaki, Ryosuke Sumiyoshi, Ritsu Yamamoto, Tadashi Saito, Sumiko Matsumoto, Kensuke Ooi, Jun Shirafuji, Naoki Medicine (Baltimore) Research Article We investigated the potential of nutritional and inflammatory parameters as prognostic factors for follicular lymphoma (FL), and also examined the predictive value of the early progression of disease within 24 months of first-line chemo-immunotherapy (POD24). We retrospectively analyzed 46 patients with FL admitted to Teikyo University Hospital and treated with chemo-immunotherapy between May 2009 and July 2019. Physical characteristics, blood parameters, and markers or scores for consumptive/inflammatory and nutritional conditions were used as variables. Nine parameters correlated with poor overall survival (OS) in univariate analysis: An Eastern Cooperative Oncology Group (ECOG) scale performance status (PS) ≥2, five or more involved nodal sites, positive bone marrow (BM) involvement, a serum albumin level <3.5 g/dL, CRP >0.5 mg/dL, lactate dehydrogenase (LD) higher than the upper normal limit (UNL), high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, modified Glasgow prognostic score of 1–2, and the geriatric nutritional risk index <82. In multivariate analysis, ECOG PS ≥2, positive BM involvement, and a serum HDL-C level <40 mg/dL remained significant for poor progression-free survival. One-year OS rate after receiving salvage chemotherapy was lower in the POD24 group (50%) and POD24 correlated with ECOG PS ≥2, positive BM involvement, a serum lactate dehydrogenase >UNL, and HDL-C <40 mg/dL by Fisher’s exact test. These results indicate that low serum HDL-C levels appear to be important for predicting the risk of POD24 and the worse prognosis of FL. Lippincott Williams & Wilkins 2022-07-29 /pmc/articles/PMC9333492/ /pubmed/35905283 http://dx.doi.org/10.1097/MD.0000000000029541 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Matsuo, Takuji Tashiro, Haruko Shirasaki, Ryosuke Sumiyoshi, Ritsu Yamamoto, Tadashi Saito, Sumiko Matsumoto, Kensuke Ooi, Jun Shirafuji, Naoki Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title | Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title_full | Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title_fullStr | Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title_full_unstemmed | Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title_short | Serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
title_sort | serum high-density lipoprotein cholesterol level has a significant prognostic impact on outcomes of follicular lymphoma patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333492/ https://www.ncbi.nlm.nih.gov/pubmed/35905283 http://dx.doi.org/10.1097/MD.0000000000029541 |
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