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Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems

Blood culture is the main tool used to identify causative pathogens. Adequate volume and number of culture sets are considered key to blood culture positivity rate. It is not known whether these factors remain critical to the positivity rate after the introduction of automated continuous blood cultu...

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Autores principales: Lin, Pei-Chin, Chang, Chia-Ling, Chung, Yi-Hua, Chang, Chih-Chun, Chu, Fang-Yeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333494/
https://www.ncbi.nlm.nih.gov/pubmed/35905221
http://dx.doi.org/10.1097/MD.0000000000029693
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author Lin, Pei-Chin
Chang, Chia-Ling
Chung, Yi-Hua
Chang, Chih-Chun
Chu, Fang-Yeh
author_facet Lin, Pei-Chin
Chang, Chia-Ling
Chung, Yi-Hua
Chang, Chih-Chun
Chu, Fang-Yeh
author_sort Lin, Pei-Chin
collection PubMed
description Blood culture is the main tool used to identify causative pathogens. Adequate volume and number of culture sets are considered key to blood culture positivity rate. It is not known whether these factors remain critical to the positivity rate after the introduction of automated continuous blood culture system monitoring. We measured blood volume per bottle and described the distribution of blood volume and number of culture sets. Multivariate logistic regression was performed to determine the independent association of blood volume, number of culture sets, diagnosis of sepsis in a patient, and other covariates with blood culture results. Only 6.9% of the blood culture bottle volumes complied with the guidance (8–10 mL), with the highest culture positivity rate (18%). Of the culture events, only one set of blood was cultured in 60.9% of events. In the multivariate analysis, blood culture volume per event (odds ratio [OR], 1.09 [95% confidence interval [CI], 1.06–1.11]), patients with a diagnosis of sepsis (OR, 2.86 [95% CI, 2.06–3.98]), and samples from the emergency department (OR, 2.29 [95% CI, 1.72–3.04]), but not the number of culture sets (OR, 0.74 [95% CI, 0.50–1.12]), were observed to be statistically significant with respect to blood culture positivity rate. Our results revealed that the total blood culture volume and the diagnosis of sepsis were critical factors affecting blood culture positivity rate. However, the proportion of blood culture bottles with the optimal blood volume was very low, and optimizing blood volume would be key to increasing blood culture positivity rate.
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spelling pubmed-93334942022-08-03 Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems Lin, Pei-Chin Chang, Chia-Ling Chung, Yi-Hua Chang, Chih-Chun Chu, Fang-Yeh Medicine (Baltimore) Research Article Blood culture is the main tool used to identify causative pathogens. Adequate volume and number of culture sets are considered key to blood culture positivity rate. It is not known whether these factors remain critical to the positivity rate after the introduction of automated continuous blood culture system monitoring. We measured blood volume per bottle and described the distribution of blood volume and number of culture sets. Multivariate logistic regression was performed to determine the independent association of blood volume, number of culture sets, diagnosis of sepsis in a patient, and other covariates with blood culture results. Only 6.9% of the blood culture bottle volumes complied with the guidance (8–10 mL), with the highest culture positivity rate (18%). Of the culture events, only one set of blood was cultured in 60.9% of events. In the multivariate analysis, blood culture volume per event (odds ratio [OR], 1.09 [95% confidence interval [CI], 1.06–1.11]), patients with a diagnosis of sepsis (OR, 2.86 [95% CI, 2.06–3.98]), and samples from the emergency department (OR, 2.29 [95% CI, 1.72–3.04]), but not the number of culture sets (OR, 0.74 [95% CI, 0.50–1.12]), were observed to be statistically significant with respect to blood culture positivity rate. Our results revealed that the total blood culture volume and the diagnosis of sepsis were critical factors affecting blood culture positivity rate. However, the proportion of blood culture bottles with the optimal blood volume was very low, and optimizing blood volume would be key to increasing blood culture positivity rate. Lippincott Williams & Wilkins 2022-07-29 /pmc/articles/PMC9333494/ /pubmed/35905221 http://dx.doi.org/10.1097/MD.0000000000029693 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Pei-Chin
Chang, Chia-Ling
Chung, Yi-Hua
Chang, Chih-Chun
Chu, Fang-Yeh
Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title_full Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title_fullStr Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title_full_unstemmed Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title_short Revisiting factors associated with blood culture positivity: Critical factors after the introduction of automated continuous monitoring blood culture systems
title_sort revisiting factors associated with blood culture positivity: critical factors after the introduction of automated continuous monitoring blood culture systems
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333494/
https://www.ncbi.nlm.nih.gov/pubmed/35905221
http://dx.doi.org/10.1097/MD.0000000000029693
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