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Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients
There is growing interest in the relationship between allergies and autoimmune diseases, although previous studies have yielded inconsistent results. The thyroglobulin (Tg)/thyroid peroxidase antibody (TPOAb) group consisted of 217 patients with positive thyroglobulin antibody (TgAb) and/or TPOAb te...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333515/ https://www.ncbi.nlm.nih.gov/pubmed/35905200 http://dx.doi.org/10.1097/MD.0000000000029871 |
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author | Zhang, Congcong Hong, Chengwei Lian, Xiaolan Wen, Liping Xu, Kun Tian, Zhuang Si, Wenjie Li, Yongning |
author_facet | Zhang, Congcong Hong, Chengwei Lian, Xiaolan Wen, Liping Xu, Kun Tian, Zhuang Si, Wenjie Li, Yongning |
author_sort | Zhang, Congcong |
collection | PubMed |
description | There is growing interest in the relationship between allergies and autoimmune diseases, although previous studies have yielded inconsistent results. The thyroglobulin (Tg)/thyroid peroxidase antibody (TPOAb) group consisted of 217 patients with positive thyroglobulin antibody (TgAb) and/or TPOAb test results. Another set of 217 age- and sex-matched individuals with both TgAb- and TPOAb-negative results were selected as control group. History of allergic rhinitis (AR), chronic spontaneous urticaria (CSU), and/or atopic dermatitis (AD) was elicited before autoantibody detection. The association of thyroid autoantibodies with allergic diseases was assessed using univariate and multivariate logistic regression analysis, and the results were reported as odds ratios (ORs). TgAb positivity (OR, 2.333) was identified as a risk factor for AR, AD, or CSU in Chinese patients, suggesting the involvement of thyroid autoantibodies in the pathogenesis of atopic reactions. Multivariate regression analysis also confirmed that the presence of TgAb (P = .004), rather than TPOAb (P = .468), had a significant impact on the occurrence of allergic disease. Physicians should carefully monitor atopic symptoms in individuals with elevated TgAb or TPOAb levels to reduce the risk of allergic diseases, such as AR, AD, and CSU. |
format | Online Article Text |
id | pubmed-9333515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93335152022-08-03 Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients Zhang, Congcong Hong, Chengwei Lian, Xiaolan Wen, Liping Xu, Kun Tian, Zhuang Si, Wenjie Li, Yongning Medicine (Baltimore) Research Article There is growing interest in the relationship between allergies and autoimmune diseases, although previous studies have yielded inconsistent results. The thyroglobulin (Tg)/thyroid peroxidase antibody (TPOAb) group consisted of 217 patients with positive thyroglobulin antibody (TgAb) and/or TPOAb test results. Another set of 217 age- and sex-matched individuals with both TgAb- and TPOAb-negative results were selected as control group. History of allergic rhinitis (AR), chronic spontaneous urticaria (CSU), and/or atopic dermatitis (AD) was elicited before autoantibody detection. The association of thyroid autoantibodies with allergic diseases was assessed using univariate and multivariate logistic regression analysis, and the results were reported as odds ratios (ORs). TgAb positivity (OR, 2.333) was identified as a risk factor for AR, AD, or CSU in Chinese patients, suggesting the involvement of thyroid autoantibodies in the pathogenesis of atopic reactions. Multivariate regression analysis also confirmed that the presence of TgAb (P = .004), rather than TPOAb (P = .468), had a significant impact on the occurrence of allergic disease. Physicians should carefully monitor atopic symptoms in individuals with elevated TgAb or TPOAb levels to reduce the risk of allergic diseases, such as AR, AD, and CSU. Lippincott Williams & Wilkins 2022-07-29 /pmc/articles/PMC9333515/ /pubmed/35905200 http://dx.doi.org/10.1097/MD.0000000000029871 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Zhang, Congcong Hong, Chengwei Lian, Xiaolan Wen, Liping Xu, Kun Tian, Zhuang Si, Wenjie Li, Yongning Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title | Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title_full | Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title_fullStr | Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title_full_unstemmed | Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title_short | Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients |
title_sort | correlations of thyroid autoantibodies with allergic diseases: a case-control study of 434 chinese patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333515/ https://www.ncbi.nlm.nih.gov/pubmed/35905200 http://dx.doi.org/10.1097/MD.0000000000029871 |
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