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A case report of IgG4-related respiratory disease with pleural effusion and a literature review
RATIONALE: IgG4-related respiratory disease (IgG4-RRD) is a chronic autoimmune disease that affects the respiratory system and organs outside the respiratory system. This study explored the diagnosis and treatment of a case of IgG4-RRD with unilateral pleural effusion diagnosed using medical thoraco...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333542/ https://www.ncbi.nlm.nih.gov/pubmed/35905235 http://dx.doi.org/10.1097/MD.0000000000029338 |
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author | Guo, Qing Ren, Yue Wang, Quanyi Pei, Hongyun Jiang, Shenghua |
author_facet | Guo, Qing Ren, Yue Wang, Quanyi Pei, Hongyun Jiang, Shenghua |
author_sort | Guo, Qing |
collection | PubMed |
description | RATIONALE: IgG4-related respiratory disease (IgG4-RRD) is a chronic autoimmune disease that affects the respiratory system and organs outside the respiratory system. This study explored the diagnosis and treatment of a case of IgG4-RRD with unilateral pleural effusion diagnosed using medical thoracoscopy, and provides an associated literature review. This report summarizes the clinical characteristics of IgG4-RRD involving the pleura to improve the diagnosis of this disease. PATIENT CONCERNS: A 39-year-old man presented with a 2-week history of cough and chest tightness. Both physical examination and imaging supported the presence of left pleural effusion. DIAGNOSIS: Medical electronic thoracoscopy was performed to obtain a pleural biopsy, which showed lymphoplasmacytic infiltration, 40 IgG4+ plasma cells per High Power Field (HPF) on microscopy, IgG4/IgG ratio >50%, phlebitis obliterans, and storiform fibrosis. The final diagnosis was IgG4-RRD. INTERVENTIONS AND OUTCOMES: The patient was treated with methylprednisolone, after which his symptoms improved, and he was discharged. Oral hormone therapy was continued outside the hospital. After 4 months, the patient returned to the hospital and his condition had improved significantly. LESSONS: Pleural involvement in IgG4-RRD is rare, and its diagnosis depends on pleural biopsy. Thoracoscopy usually reveals pleural thickening, pleural nodules, and milky white plaques. |
format | Online Article Text |
id | pubmed-9333542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93335422022-08-03 A case report of IgG4-related respiratory disease with pleural effusion and a literature review Guo, Qing Ren, Yue Wang, Quanyi Pei, Hongyun Jiang, Shenghua Medicine (Baltimore) Research Article RATIONALE: IgG4-related respiratory disease (IgG4-RRD) is a chronic autoimmune disease that affects the respiratory system and organs outside the respiratory system. This study explored the diagnosis and treatment of a case of IgG4-RRD with unilateral pleural effusion diagnosed using medical thoracoscopy, and provides an associated literature review. This report summarizes the clinical characteristics of IgG4-RRD involving the pleura to improve the diagnosis of this disease. PATIENT CONCERNS: A 39-year-old man presented with a 2-week history of cough and chest tightness. Both physical examination and imaging supported the presence of left pleural effusion. DIAGNOSIS: Medical electronic thoracoscopy was performed to obtain a pleural biopsy, which showed lymphoplasmacytic infiltration, 40 IgG4+ plasma cells per High Power Field (HPF) on microscopy, IgG4/IgG ratio >50%, phlebitis obliterans, and storiform fibrosis. The final diagnosis was IgG4-RRD. INTERVENTIONS AND OUTCOMES: The patient was treated with methylprednisolone, after which his symptoms improved, and he was discharged. Oral hormone therapy was continued outside the hospital. After 4 months, the patient returned to the hospital and his condition had improved significantly. LESSONS: Pleural involvement in IgG4-RRD is rare, and its diagnosis depends on pleural biopsy. Thoracoscopy usually reveals pleural thickening, pleural nodules, and milky white plaques. Lippincott Williams & Wilkins 2022-07-29 /pmc/articles/PMC9333542/ /pubmed/35905235 http://dx.doi.org/10.1097/MD.0000000000029338 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Guo, Qing Ren, Yue Wang, Quanyi Pei, Hongyun Jiang, Shenghua A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title | A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title_full | A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title_fullStr | A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title_full_unstemmed | A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title_short | A case report of IgG4-related respiratory disease with pleural effusion and a literature review |
title_sort | case report of igg4-related respiratory disease with pleural effusion and a literature review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333542/ https://www.ncbi.nlm.nih.gov/pubmed/35905235 http://dx.doi.org/10.1097/MD.0000000000029338 |
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