An entropic safety catch controls hepatitis C virus entry and antibody resistance

E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2 is a putative intrinsically disordered protein tail. Here, we demonstrate...

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Detalles Bibliográficos
Autores principales: Stejskal, Lenka, Kalemera, Mphatso D, Lewis, Charlotte B, Palor, Machaela, Walker, Lucas, Daviter, Tina, Lees, William D, Moss, David S, Kremyda-Vlachou, Myrto, Kozlakidis, Zisis, Gallo, Giulia, Bailey, Dalan, Rosenberg, William, Illingworth, Christopher JR, Shepherd, Adrian J, Grove, Joe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333995/
https://www.ncbi.nlm.nih.gov/pubmed/35796426
http://dx.doi.org/10.7554/eLife.71854

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