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Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban

BACKGROUND: Anticoagulation with warfarin remains the mainstay treatment for left ventricular thrombi. Although successful thrombus resolution has been reported with direct oral anticoagulants' (DOACs') recurrence/progression while resuming Apixaban therapy is yet to be reported. Case Pres...

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Autores principales: Farooqui, Azhar, Lwin, Tin, Costa, Daniel, Hetherington, Simon, Mattu, Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334074/
https://www.ncbi.nlm.nih.gov/pubmed/35911864
http://dx.doi.org/10.1155/2022/8156942
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author Farooqui, Azhar
Lwin, Tin
Costa, Daniel
Hetherington, Simon
Mattu, Raj
author_facet Farooqui, Azhar
Lwin, Tin
Costa, Daniel
Hetherington, Simon
Mattu, Raj
author_sort Farooqui, Azhar
collection PubMed
description BACKGROUND: Anticoagulation with warfarin remains the mainstay treatment for left ventricular thrombi. Although successful thrombus resolution has been reported with direct oral anticoagulants' (DOACs') recurrence/progression while resuming Apixaban therapy is yet to be reported. Case Presentation. This case report describes left ventricular thrombus progression/recurrence in a patient anticoagulated with Apixaban undergoing implantable cardioverter defibrillator to cardiac resynchronisation therapy with defibrillator upgrade procedure. He was thereafter changed to warfarin. Contrast echocardiogram at 6 months follow-up did not identify the previously demonstrated mural thrombus. CONCLUSION: Prospective randomised control trials should be conducted in patients with left ventricular thrombus to compare anticoagulants, assess the efficacy and safety of DOACs, and evaluate uninterrupted DOAC versus transient withdrawal for cardiac device procedures.
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spelling pubmed-93340742022-07-29 Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban Farooqui, Azhar Lwin, Tin Costa, Daniel Hetherington, Simon Mattu, Raj Case Rep Cardiol Case Report BACKGROUND: Anticoagulation with warfarin remains the mainstay treatment for left ventricular thrombi. Although successful thrombus resolution has been reported with direct oral anticoagulants' (DOACs') recurrence/progression while resuming Apixaban therapy is yet to be reported. Case Presentation. This case report describes left ventricular thrombus progression/recurrence in a patient anticoagulated with Apixaban undergoing implantable cardioverter defibrillator to cardiac resynchronisation therapy with defibrillator upgrade procedure. He was thereafter changed to warfarin. Contrast echocardiogram at 6 months follow-up did not identify the previously demonstrated mural thrombus. CONCLUSION: Prospective randomised control trials should be conducted in patients with left ventricular thrombus to compare anticoagulants, assess the efficacy and safety of DOACs, and evaluate uninterrupted DOAC versus transient withdrawal for cardiac device procedures. Hindawi 2022-07-21 /pmc/articles/PMC9334074/ /pubmed/35911864 http://dx.doi.org/10.1155/2022/8156942 Text en Copyright © 2022 Azhar Farooqui et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Farooqui, Azhar
Lwin, Tin
Costa, Daniel
Hetherington, Simon
Mattu, Raj
Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title_full Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title_fullStr Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title_full_unstemmed Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title_short Recurrence of LV Thrombus in a Patient with Severe Ischaemic Cardiomyopathy Anticoagulated with Apixaban
title_sort recurrence of lv thrombus in a patient with severe ischaemic cardiomyopathy anticoagulated with apixaban
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334074/
https://www.ncbi.nlm.nih.gov/pubmed/35911864
http://dx.doi.org/10.1155/2022/8156942
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