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Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine

Immune thrombocytopenia (ITP) has been associated with immunizations with various proposed mechanisms, including overactivation of the immune system and production of antibodies against circulating platelets. ITP has also been associated with several viral infections, including HCV, HIV, and most re...

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Detalles Bibliográficos
Autores principales: Antonios, Bana, Zimmer, Markie, Herrman, Emma, Berghea, Ramona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334126/
https://www.ncbi.nlm.nih.gov/pubmed/35911081
http://dx.doi.org/10.1155/2022/7208401
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author Antonios, Bana
Zimmer, Markie
Herrman, Emma
Berghea, Ramona
author_facet Antonios, Bana
Zimmer, Markie
Herrman, Emma
Berghea, Ramona
author_sort Antonios, Bana
collection PubMed
description Immune thrombocytopenia (ITP) has been associated with immunizations with various proposed mechanisms, including overactivation of the immune system and production of antibodies against circulating platelets. ITP has also been associated with several viral infections, including HCV, HIV, and most recently, active SARS-CoV-2 infection. Here, we present a case of a 52-year-old male with no past medical history who sought evaluation with his primary care physician for upper and lower extremity ecchymosis of one week duration. Outpatient laboratory studies were notable for severe isolated thrombocytopenia with platelet count of 8 × 10(^)9/L. Interestingly, he received the Johnson and Johnson COVID-19 vaccine 16 days prior to his presentation. Clinical work up and laboratory investigations led to the diagnosis of ITP.
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spelling pubmed-93341262022-07-29 Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine Antonios, Bana Zimmer, Markie Herrman, Emma Berghea, Ramona Case Rep Hematol Case Report Immune thrombocytopenia (ITP) has been associated with immunizations with various proposed mechanisms, including overactivation of the immune system and production of antibodies against circulating platelets. ITP has also been associated with several viral infections, including HCV, HIV, and most recently, active SARS-CoV-2 infection. Here, we present a case of a 52-year-old male with no past medical history who sought evaluation with his primary care physician for upper and lower extremity ecchymosis of one week duration. Outpatient laboratory studies were notable for severe isolated thrombocytopenia with platelet count of 8 × 10(^)9/L. Interestingly, he received the Johnson and Johnson COVID-19 vaccine 16 days prior to his presentation. Clinical work up and laboratory investigations led to the diagnosis of ITP. Hindawi 2022-07-27 /pmc/articles/PMC9334126/ /pubmed/35911081 http://dx.doi.org/10.1155/2022/7208401 Text en Copyright © 2022 Bana Antonios et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Antonios, Bana
Zimmer, Markie
Herrman, Emma
Berghea, Ramona
Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title_full Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title_fullStr Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title_full_unstemmed Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title_short Severe Thrombocytopenia Two Weeks Following Immunization with the Janssen Ad26.CoV2.S Vaccine
title_sort severe thrombocytopenia two weeks following immunization with the janssen ad26.cov2.s vaccine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334126/
https://www.ncbi.nlm.nih.gov/pubmed/35911081
http://dx.doi.org/10.1155/2022/7208401
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