IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis

A 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and hematuria were observed, which worsened after seven courses. He was diagnosed with a combination of IgA nephropathy and active interstitial...

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Autores principales: Mitarai, Yuki, Nakashima, Kazuhisa, Fukunaga, Shohei, Ishikawa, Noriyoshi, Ito, Takafumi, Tsubata, Yukari, Isobe, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334229/
https://www.ncbi.nlm.nih.gov/pubmed/34840226
http://dx.doi.org/10.2169/internalmedicine.7115-21
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author Mitarai, Yuki
Nakashima, Kazuhisa
Fukunaga, Shohei
Ishikawa, Noriyoshi
Ito, Takafumi
Tsubata, Yukari
Isobe, Takeshi
author_facet Mitarai, Yuki
Nakashima, Kazuhisa
Fukunaga, Shohei
Ishikawa, Noriyoshi
Ito, Takafumi
Tsubata, Yukari
Isobe, Takeshi
author_sort Mitarai, Yuki
collection PubMed
description A 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and hematuria were observed, which worsened after seven courses. He was diagnosed with a combination of IgA nephropathy and active interstitial nephritis. Steroid pulse therapy was started, and the dose of prednisolone was gradually reduced from 60 mg/day. Renal dysfunction as an immune-related adverse event of pembrolizumab monotherapy for non-small cell lung cancer has been reported previously. Therefore, establishing a system for the early detection and treatment that distinguishes immune-related glomerular diseases is essential.
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spelling pubmed-93342292022-08-15 IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis Mitarai, Yuki Nakashima, Kazuhisa Fukunaga, Shohei Ishikawa, Noriyoshi Ito, Takafumi Tsubata, Yukari Isobe, Takeshi Intern Med Case Report A 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and hematuria were observed, which worsened after seven courses. He was diagnosed with a combination of IgA nephropathy and active interstitial nephritis. Steroid pulse therapy was started, and the dose of prednisolone was gradually reduced from 60 mg/day. Renal dysfunction as an immune-related adverse event of pembrolizumab monotherapy for non-small cell lung cancer has been reported previously. Therefore, establishing a system for the early detection and treatment that distinguishes immune-related glomerular diseases is essential. The Japanese Society of Internal Medicine 2021-11-27 2022-07-01 /pmc/articles/PMC9334229/ /pubmed/34840226 http://dx.doi.org/10.2169/internalmedicine.7115-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mitarai, Yuki
Nakashima, Kazuhisa
Fukunaga, Shohei
Ishikawa, Noriyoshi
Ito, Takafumi
Tsubata, Yukari
Isobe, Takeshi
IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title_full IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title_fullStr IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title_full_unstemmed IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title_short IgA Nephropathy that Developed as an Immune-related Adverse Event of Pembrolizumab Complicated with Interstitial Nephritis
title_sort iga nephropathy that developed as an immune-related adverse event of pembrolizumab complicated with interstitial nephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334229/
https://www.ncbi.nlm.nih.gov/pubmed/34840226
http://dx.doi.org/10.2169/internalmedicine.7115-21
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