Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus

We herein report a 60-year-old woman who experienced severe flare of rheumatoid arthritis (RA) and Epstein-Barr virus (EBV) positivity following administration of the messenger ribonucleic acid (mRNA)-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Since 40 years old, she...

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Autores principales: Nakamura, Hideki, Nagasawa, Yosuke, Kobayashi, Hitomi, Tsukamoto, Masako, Takayama, Tadateru, Kitamura, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334251/
https://www.ncbi.nlm.nih.gov/pubmed/35466171
http://dx.doi.org/10.2169/internalmedicine.9433-22
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author Nakamura, Hideki
Nagasawa, Yosuke
Kobayashi, Hitomi
Tsukamoto, Masako
Takayama, Tadateru
Kitamura, Noboru
author_facet Nakamura, Hideki
Nagasawa, Yosuke
Kobayashi, Hitomi
Tsukamoto, Masako
Takayama, Tadateru
Kitamura, Noboru
author_sort Nakamura, Hideki
collection PubMed
description We herein report a 60-year-old woman who experienced severe flare of rheumatoid arthritis (RA) and Epstein-Barr virus (EBV) positivity following administration of the messenger ribonucleic acid (mRNA)-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Since 40 years old, she had been in long-term remission of anti-citrullinated protein antibody-positive RA. Ten days after SARS-CoV-2 vaccination, she presented with a high fever and polyarthritis, active synovitis on joint ultrasound, a clinical disease activity index of 35, and positivity for anti-early antigen, diffuse type and restricted type (EA DR) IgG and EBV deoxyribonucleic acid (EBV-DNA). Tocilizumab was introduced to treat RA. The RA disease activity disappeared, and anti-EA DR IgG and EBV-DNA became negative.
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spelling pubmed-93342512022-08-15 Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus Nakamura, Hideki Nagasawa, Yosuke Kobayashi, Hitomi Tsukamoto, Masako Takayama, Tadateru Kitamura, Noboru Intern Med Case Report We herein report a 60-year-old woman who experienced severe flare of rheumatoid arthritis (RA) and Epstein-Barr virus (EBV) positivity following administration of the messenger ribonucleic acid (mRNA)-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Since 40 years old, she had been in long-term remission of anti-citrullinated protein antibody-positive RA. Ten days after SARS-CoV-2 vaccination, she presented with a high fever and polyarthritis, active synovitis on joint ultrasound, a clinical disease activity index of 35, and positivity for anti-early antigen, diffuse type and restricted type (EA DR) IgG and EBV deoxyribonucleic acid (EBV-DNA). Tocilizumab was introduced to treat RA. The RA disease activity disappeared, and anti-EA DR IgG and EBV-DNA became negative. The Japanese Society of Internal Medicine 2022-04-23 2022-07-01 /pmc/articles/PMC9334251/ /pubmed/35466171 http://dx.doi.org/10.2169/internalmedicine.9433-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakamura, Hideki
Nagasawa, Yosuke
Kobayashi, Hitomi
Tsukamoto, Masako
Takayama, Tadateru
Kitamura, Noboru
Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title_full Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title_fullStr Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title_full_unstemmed Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title_short Successful Treatment of SARS-CoV-2 Vaccination-related Activation of Rheumatoid Arthritis with Positive Findings for Epstein-Barr Virus
title_sort successful treatment of sars-cov-2 vaccination-related activation of rheumatoid arthritis with positive findings for epstein-barr virus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334251/
https://www.ncbi.nlm.nih.gov/pubmed/35466171
http://dx.doi.org/10.2169/internalmedicine.9433-22
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