A unique class of Zn(2+)-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Treatment with β-lactam antibiotics, particularly cephalosporins, is a major risk factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly inhibit penicillin-binding proteins (PBPs), which are serine-based enzymes that assemble the bacterial cell wall. However, C....

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Detalles Bibliográficos
Autores principales: Sacco, Michael D., Wang, Shaohui, Adapa, Swamy R., Zhang, Xiujun, Lewandowski, Eric M., Gongora, Maura V., Keramisanou, Dimitra, Atlas, Zachary D., Townsend, Julia A., Gatdula, Jean R., Morgan, Ryan T., Hammond, Lauren R., Marty, Michael T., Wang, Jun, Eswara, Prahathees J., Gelis, Ioannis, Jiang, Rays H. Y., Sun, Xingmin, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334274/
https://www.ncbi.nlm.nih.gov/pubmed/35902581
http://dx.doi.org/10.1038/s41467-022-32086-6

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