The substitution at residue 218 of the NS5 protein methyltransferase domain of Tembusu virus impairs viral replication and translation and may triggers RIG-I-like receptor signaling

Flavivirus RNA cap-methylation plays an important role in viral infection, proliferation, and escape from innate immunity. The methyltransferase (MTase) of the flavivirus NS5 protein catalyzes viral RNA methylation. The E218 amino acid of the NS5 protein MTase domain is one of the active sites of fl...

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Detalles Bibliográficos
Autores principales: Wu, Xuedong, Pan, Yuhong, Huang, Juan, Huang, Shanzhi, Wang, Mingshu, Chen, Shun, Liu, Mafeng, Zhu, Dekang, Zhao, Xinxin, Wu, Ying, Yang, Qiao, Zhang, Shaqiu, Ou, Xumin, Zhang, Ling, Liu, Yunya, Yu, Yanling, Gao, Qun, Mao, Sai, Sun, Di, Tian, Bin, Yin, Zhongqiong, Jing, Bo, Cheng, Anchun, Jia, Renyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
IMMUNOLOGY, HEALTH AND DISEASE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334331/
https://www.ncbi.nlm.nih.gov/pubmed/35901648
http://dx.doi.org/10.1016/j.psj.2022.102017

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