High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy

The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily increased with increased colistin usage for treating carbapenem-resistant K. pneumoniae (CRkp). Our study demonstrated the r...

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Detalles Bibliográficos
Autores principales: Shein, Aye Mya Sithu, Wannigama, Dhammika Leshan, Higgins, Paul G., Hurst, Cameron, Abe, Shuichi, Hongsing, Parichart, Chantaravisoot, Naphat, Saethang, Thammakorn, Luk-in, Sirirat, Liao, Tingting, Nilgate, Sumanee, Rirerm, Ubolrat, Kueakulpattana, Naris, Srisakul, Sukrit, Aryukarn, Apichaya, Laowansiri, Matchima, Hao, Lee Yin, Yonpiam, Manta, Ragupathi, Naveen Kumar Devanga, Techawiwattanaboon, Teerasit, Ngamwongsatit, Natharin, Amarasiri, Mohan, Ounjai, Puey, Kupwiwat, Rosalyn, Phattharapornjaroen, Phatthranit, Badavath, Vishnu Nayak, Leelahavanichkul, Asada, Kicic, Anthony, Chatsuwan, Tanittha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334626/
https://www.ncbi.nlm.nih.gov/pubmed/35902639
http://dx.doi.org/10.1038/s41598-022-17083-5

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