Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage whole genome sequencing analyses from fifteen cohorts in NHLBI’s Trans-Omics for Precision Med...

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Detalles Bibliográficos
Autores principales: DiCorpo, Daniel, Gaynor, Sheila M., Russell, Emily M., Westerman, Kenneth E., Raffield, Laura M., Majarian, Timothy D., Wu, Peitao, Sarnowski, Chloé, Highland, Heather M., Jackson, Anne, Hasbani, Natalie R., de Vries, Paul S., Brody, Jennifer A., Hidalgo, Bertha, Guo, Xiuqing, Perry, James A., O’Connell, Jeffrey R., Lent, Samantha, Montasser, May E., Cade, Brian E., Jain, Deepti, Wang, Heming, D’Oliveira Albanus, Ricardo, Varshney, Arushi, Yanek, Lisa R., Lange, Leslie, Palmer, Nicholette D., Almeida, Marcio, Peralta, Juan M., Aslibekyan, Stella, Baldridge, Abigail S., Bertoni, Alain G., Bielak, Lawrence F., Chen, Chung-Shiuan, Chen, Yii-Der Ida, Choi, Won Jung, Goodarzi, Mark O., Floyd, James S., Irvin, Marguerite R., Kalyani, Rita R., Kelly, Tanika N., Lee, Seonwook, Liu, Ching-Ti, Loesch, Douglas, Manson, JoAnn E., Minster, Ryan L., Naseri, Take, Pankow, James S., Rasmussen-Torvik, Laura J., Reiner, Alexander P., Reupena, Muagututi’a Sefuiva, Selvin, Elizabeth, Smith, Jennifer A., Weeks, Daniel E., Xu, Huichun, Yao, Jie, Zhao, Wei, Parker, Stephen, Alonso, Alvaro, Arnett, Donna K., Blangero, John, Boerwinkle, Eric, Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Duggirala, Ravindranath, He, Jiang, Heckbert, Susan R., Kardia, Sharon L. R., Kim, Ryan W., Kooperberg, Charles, Liu, Simin, Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Morrison, Alanna C., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Shuldiner, Alan R., Taylor, Kent D., Vasan, Ramachandran S., Viaud-Martinez, Karine A., Florez, Jose C., Wilson, James G., Sladek, Robert, Rich, Stephen S., Rotter, Jerome I., Lin, Xihong, Dupuis, Josée, Meigs, James B., Wessel, Jennifer, Manning, Alisa K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334637/
https://www.ncbi.nlm.nih.gov/pubmed/35902682
http://dx.doi.org/10.1038/s42003-022-03702-4

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