Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism

Palmitic acid (PA) is significantly increased in the hypothalamus of mice, when fed chronically with a high-fat diet (HFD). PA impairs insulin signaling in hypothalamic neurons, by a mechanism dependent on autophagy, a process of lysosomal-mediated degradation of cytoplasmic material. In addition, p...

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Detalles Bibliográficos
Autores principales: Ávalos, Yenniffer, Hernández-Cáceres, María Paz, Lagos, Pablo, Pinto-Nuñez, Daniela, Rivera, Patricia, Burgos, Paulina, Díaz-Castro, Francisco, Joy-Immediato, Michelle, Venegas-Zamora, Leslye, Lopez-Gallardo, Erik, Kretschmar, Catalina, Batista-Gonzalez, Ana, Cifuentes-Araneda, Flavia, Toledo-Valenzuela, Lilian, Rodriguez-Peña, Marcelo, Espinoza-Caicedo, Jasson, Perez-Leighton, Claudio, Bertocchi, Cristina, Cerda, Mauricio, Troncoso, Rodrigo, Parra, Valentina, Budini, Mauricio, Burgos, Patricia V., Criollo, Alfredo, Morselli, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334645/
https://www.ncbi.nlm.nih.gov/pubmed/35902579
http://dx.doi.org/10.1038/s41419-022-05109-9

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