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The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19
OBJECTIVE: To assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and PTSD. METHODS: This was a prospective cohort study of consecutive patients dischar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334651/ https://www.ncbi.nlm.nih.gov/pubmed/35911221 http://dx.doi.org/10.3389/fpsyt.2022.931349 |
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author | Stavem, Knut Heir, Trond Dammen, Toril Brønstad, Eivind Lerum, Tøri Vigeland Durheim, Michael T. Lund, Kristine M. A. Aarli, Bernt B. Einvik, Gunnar |
author_facet | Stavem, Knut Heir, Trond Dammen, Toril Brønstad, Eivind Lerum, Tøri Vigeland Durheim, Michael T. Lund, Kristine M. A. Aarli, Bernt B. Einvik, Gunnar |
author_sort | Stavem, Knut |
collection | PubMed |
description | OBJECTIVE: To assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and PTSD. METHODS: This was a prospective cohort study of consecutive patients discharged after hospitalization for COVID-19 before 1 June 2020 in six hospitals in Southern Norway. Symptom-defined PTSD was assessed by the post-traumatic stress disorder (PTSD) checklist for DSM-5 (PCL-5) at 1.5, 3 and/or 12 months after hospitalization, using DSM-5 criteria. Changes in PCL-5 symptom score and the prevalence of PTSD were analyzed with multivariable mixed models. RESULTS: In total, 388 patients were discharged alive, and 251 (65%) participated. Respondents had a mean (SD) age of 58.4 (14.2) years, and 142 (57%) were males. The prevalence of symptom-defined PTSD was 14, 8, and 9% at 1.5, 3, and 12 months, respectively. WHO disease severity for COVID-19 was not associated with PCL-5 scores. Female sex, lower age and non-Norwegian origin were associated with higher PCL-5 scores. The odds ratio (OR) (95%CI) for PTSD was 0.32 (0.12 to 0.83, p = 0.019) at 3 months and 0.38 (0.15 to 0.95, p = 0.039) at 12 months compared to 1.5 months. There was no association between PTSD and WHO severity rating. CONCLUSIONS: The level of PTSD symptoms decreased from 1.5 to 3 months after hospitalization, but did not decrease further to 12 months, and there was no association between PTSD symptoms and COVID-19 disease severity. |
format | Online Article Text |
id | pubmed-9334651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93346512022-07-30 The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 Stavem, Knut Heir, Trond Dammen, Toril Brønstad, Eivind Lerum, Tøri Vigeland Durheim, Michael T. Lund, Kristine M. A. Aarli, Bernt B. Einvik, Gunnar Front Psychiatry Psychiatry OBJECTIVE: To assess the trajectory of symptoms and symptom-defined post-traumatic stress disorder (PTSD) from 1.5 to 12 months after hospitalization for COVID-19 and determine risk factors for persistent symptoms and PTSD. METHODS: This was a prospective cohort study of consecutive patients discharged after hospitalization for COVID-19 before 1 June 2020 in six hospitals in Southern Norway. Symptom-defined PTSD was assessed by the post-traumatic stress disorder (PTSD) checklist for DSM-5 (PCL-5) at 1.5, 3 and/or 12 months after hospitalization, using DSM-5 criteria. Changes in PCL-5 symptom score and the prevalence of PTSD were analyzed with multivariable mixed models. RESULTS: In total, 388 patients were discharged alive, and 251 (65%) participated. Respondents had a mean (SD) age of 58.4 (14.2) years, and 142 (57%) were males. The prevalence of symptom-defined PTSD was 14, 8, and 9% at 1.5, 3, and 12 months, respectively. WHO disease severity for COVID-19 was not associated with PCL-5 scores. Female sex, lower age and non-Norwegian origin were associated with higher PCL-5 scores. The odds ratio (OR) (95%CI) for PTSD was 0.32 (0.12 to 0.83, p = 0.019) at 3 months and 0.38 (0.15 to 0.95, p = 0.039) at 12 months compared to 1.5 months. There was no association between PTSD and WHO severity rating. CONCLUSIONS: The level of PTSD symptoms decreased from 1.5 to 3 months after hospitalization, but did not decrease further to 12 months, and there was no association between PTSD symptoms and COVID-19 disease severity. Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9334651/ /pubmed/35911221 http://dx.doi.org/10.3389/fpsyt.2022.931349 Text en Copyright © 2022 Stavem, Heir, Dammen, Brønstad, Lerum, Durheim, Lund, Aarli and Einvik. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Stavem, Knut Heir, Trond Dammen, Toril Brønstad, Eivind Lerum, Tøri Vigeland Durheim, Michael T. Lund, Kristine M. A. Aarli, Bernt B. Einvik, Gunnar The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title | The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title_full | The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title_fullStr | The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title_full_unstemmed | The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title_short | The course and determinants of post-traumatic stress over 12 months after hospitalization for COVID-19 |
title_sort | course and determinants of post-traumatic stress over 12 months after hospitalization for covid-19 |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334651/ https://www.ncbi.nlm.nih.gov/pubmed/35911221 http://dx.doi.org/10.3389/fpsyt.2022.931349 |
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