Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors

Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tum...

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Autores principales: Wu, Tianqi, Wan, Jian, Xia, Kai, Yang, Muqing, Feng, Lijin, Yin, Lu, Chen, Chunqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334672/
https://www.ncbi.nlm.nih.gov/pubmed/35912179
http://dx.doi.org/10.3389/fonc.2022.910264
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author Wu, Tianqi
Wan, Jian
Xia, Kai
Yang, Muqing
Feng, Lijin
Yin, Lu
Chen, Chunqiu
author_facet Wu, Tianqi
Wan, Jian
Xia, Kai
Yang, Muqing
Feng, Lijin
Yin, Lu
Chen, Chunqiu
author_sort Wu, Tianqi
collection PubMed
description Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tumors and blood was performed to determine their clonal origin and identify genetic cancer susceptibility. NGS identified that germline genetic variants potentially correlated with an individual risk of developing multiple cancers and that additional mutations are required to drive the formation of different tumors.
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spelling pubmed-93346722022-07-30 Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors Wu, Tianqi Wan, Jian Xia, Kai Yang, Muqing Feng, Lijin Yin, Lu Chen, Chunqiu Front Oncol Oncology Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tumors and blood was performed to determine their clonal origin and identify genetic cancer susceptibility. NGS identified that germline genetic variants potentially correlated with an individual risk of developing multiple cancers and that additional mutations are required to drive the formation of different tumors. Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9334672/ /pubmed/35912179 http://dx.doi.org/10.3389/fonc.2022.910264 Text en Copyright © 2022 Wu, Wan, Xia, Yang, Feng, Yin and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Tianqi
Wan, Jian
Xia, Kai
Yang, Muqing
Feng, Lijin
Yin, Lu
Chen, Chunqiu
Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title_full Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title_fullStr Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title_full_unstemmed Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title_short Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
title_sort case report: next-generation sequencing-based detection in a patient with three synchronous primary tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334672/
https://www.ncbi.nlm.nih.gov/pubmed/35912179
http://dx.doi.org/10.3389/fonc.2022.910264
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