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Targeting skeletal muscle mitochondrial health in obesity

Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are alte...

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Autores principales: Pileggi, Chantal A., Hooks, Breana G., McPherson, Ruth, Dent, Robert R.M., Harper, Mary-Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334731/
https://www.ncbi.nlm.nih.gov/pubmed/35892309
http://dx.doi.org/10.1042/CS20210506
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author Pileggi, Chantal A.
Hooks, Breana G.
McPherson, Ruth
Dent, Robert R.M.
Harper, Mary-Ellen
author_facet Pileggi, Chantal A.
Hooks, Breana G.
McPherson, Ruth
Dent, Robert R.M.
Harper, Mary-Ellen
author_sort Pileggi, Chantal A.
collection PubMed
description Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity.
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spelling pubmed-93347312022-08-09 Targeting skeletal muscle mitochondrial health in obesity Pileggi, Chantal A. Hooks, Breana G. McPherson, Ruth Dent, Robert R.M. Harper, Mary-Ellen Clin Sci (Lond) Diabetes & Metabolic Disorders Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity. Portland Press Ltd. 2022-07 2022-07-27 /pmc/articles/PMC9334731/ /pubmed/35892309 http://dx.doi.org/10.1042/CS20210506 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Diabetes & Metabolic Disorders
Pileggi, Chantal A.
Hooks, Breana G.
McPherson, Ruth
Dent, Robert R.M.
Harper, Mary-Ellen
Targeting skeletal muscle mitochondrial health in obesity
title Targeting skeletal muscle mitochondrial health in obesity
title_full Targeting skeletal muscle mitochondrial health in obesity
title_fullStr Targeting skeletal muscle mitochondrial health in obesity
title_full_unstemmed Targeting skeletal muscle mitochondrial health in obesity
title_short Targeting skeletal muscle mitochondrial health in obesity
title_sort targeting skeletal muscle mitochondrial health in obesity
topic Diabetes & Metabolic Disorders
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334731/
https://www.ncbi.nlm.nih.gov/pubmed/35892309
http://dx.doi.org/10.1042/CS20210506
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