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Targeting skeletal muscle mitochondrial health in obesity
Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are alte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334731/ https://www.ncbi.nlm.nih.gov/pubmed/35892309 http://dx.doi.org/10.1042/CS20210506 |
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author | Pileggi, Chantal A. Hooks, Breana G. McPherson, Ruth Dent, Robert R.M. Harper, Mary-Ellen |
author_facet | Pileggi, Chantal A. Hooks, Breana G. McPherson, Ruth Dent, Robert R.M. Harper, Mary-Ellen |
author_sort | Pileggi, Chantal A. |
collection | PubMed |
description | Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity. |
format | Online Article Text |
id | pubmed-9334731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93347312022-08-09 Targeting skeletal muscle mitochondrial health in obesity Pileggi, Chantal A. Hooks, Breana G. McPherson, Ruth Dent, Robert R.M. Harper, Mary-Ellen Clin Sci (Lond) Diabetes & Metabolic Disorders Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch between fatty acid and glucose substrates) are altered in obesity, with some changes proceeding and some following the development of the disease. Nonetheless, there are marked interindividual differences in skeletal muscle composition and metabolism in obesity, some of which have been associated with obesity risk and weight loss capacity. In this review, we discuss related molecular mechanisms and how current and novel treatment strategies may enhance weight loss capacity, particularly in diet-resistant obesity. Portland Press Ltd. 2022-07 2022-07-27 /pmc/articles/PMC9334731/ /pubmed/35892309 http://dx.doi.org/10.1042/CS20210506 Text en © 2022 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Diabetes & Metabolic Disorders Pileggi, Chantal A. Hooks, Breana G. McPherson, Ruth Dent, Robert R.M. Harper, Mary-Ellen Targeting skeletal muscle mitochondrial health in obesity |
title | Targeting skeletal muscle mitochondrial health in obesity |
title_full | Targeting skeletal muscle mitochondrial health in obesity |
title_fullStr | Targeting skeletal muscle mitochondrial health in obesity |
title_full_unstemmed | Targeting skeletal muscle mitochondrial health in obesity |
title_short | Targeting skeletal muscle mitochondrial health in obesity |
title_sort | targeting skeletal muscle mitochondrial health in obesity |
topic | Diabetes & Metabolic Disorders |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334731/ https://www.ncbi.nlm.nih.gov/pubmed/35892309 http://dx.doi.org/10.1042/CS20210506 |
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