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Bilirubin inhibits the anticancer activity of sorafenib by blocking MCL-1 degradation in hepatocellular carcinoma cells
OBJECTIVE: Sorafenib is a first-line drug for advanced hepatocellular carcinoma (HCC). Unfortunately, most patients with HCC do not respond to sorafenib, mainly because of the frequent development of drug resistance. Bilirubin is an end metabolite of heme catabolism and an indicator of liver functio...
Autores principales: | Yao, Leyi, Zhao, Qian, Yan, Ding, Lei, Ziying, Hao, Yali, Chen, Jinghong, Xue, Qian, Li, Xiaofen, Huang, Qingtian, Tang, Daolin, Dou, Q. Ping, Chen, Xin, Liu, Jinbao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Compuscript
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334754/ https://www.ncbi.nlm.nih.gov/pubmed/35604090 http://dx.doi.org/10.20892/j.issn.2095-3941.2021.0598 |
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