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Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature

Primary hepatic neuroendocrine carcinoma (PHNEC) manifests as a rare type of liver tumor. PHNEC is not specifically clinical or radiographical and is often misdiagnosed and mistreated. Here, we present a case report of PHNEC in a 50-year-old woman who was admitted to our department with concealed pa...

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Autores principales: Huang, Keyu, Lan, Zhujing, Chen, Weitao, Zhang, Jianyong, Wang, Jilong, Zhu, Hai, Xu, Banghao, Zhang, Ling, Lu, Tingting, Guo, Ya, Wen, Zhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334775/
https://www.ncbi.nlm.nih.gov/pubmed/35910478
http://dx.doi.org/10.3389/fsurg.2022.920276
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author Huang, Keyu
Lan, Zhujing
Chen, Weitao
Zhang, Jianyong
Wang, Jilong
Zhu, Hai
Xu, Banghao
Zhang, Ling
Lu, Tingting
Guo, Ya
Wen, Zhang
author_facet Huang, Keyu
Lan, Zhujing
Chen, Weitao
Zhang, Jianyong
Wang, Jilong
Zhu, Hai
Xu, Banghao
Zhang, Ling
Lu, Tingting
Guo, Ya
Wen, Zhang
author_sort Huang, Keyu
collection PubMed
description Primary hepatic neuroendocrine carcinoma (PHNEC) manifests as a rare type of liver tumor. PHNEC is not specifically clinical or radiographical and is often misdiagnosed and mistreated. Here, we present a case report of PHNEC in a 50-year-old woman who was admitted to our department with concealed pain in the right upper abdomen. The initial diagnosis was a probable hepatic space-occupying lesion with tumor bleeding. The patient was subjected to a partial right hemihepatectomy, cholecystectomy, partial resection of the lower lobe of the right lung, partial resection of the diaphragm, and resection of the right perirenal fat sac to alleviate her symptoms. After surgery, gene sequencing was performed to determine the possible cause of the condition. However, five months after discharge, the patient was hospitalized again because of retroperitoneal and peritoneal multiple metastases. Nine months after surgery, the patient died. This case is likely to aid in furthering our understanding of PHNEC to improve the future diagnosis and treatment of this disease.
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spelling pubmed-93347752022-07-30 Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature Huang, Keyu Lan, Zhujing Chen, Weitao Zhang, Jianyong Wang, Jilong Zhu, Hai Xu, Banghao Zhang, Ling Lu, Tingting Guo, Ya Wen, Zhang Front Surg Surgery Primary hepatic neuroendocrine carcinoma (PHNEC) manifests as a rare type of liver tumor. PHNEC is not specifically clinical or radiographical and is often misdiagnosed and mistreated. Here, we present a case report of PHNEC in a 50-year-old woman who was admitted to our department with concealed pain in the right upper abdomen. The initial diagnosis was a probable hepatic space-occupying lesion with tumor bleeding. The patient was subjected to a partial right hemihepatectomy, cholecystectomy, partial resection of the lower lobe of the right lung, partial resection of the diaphragm, and resection of the right perirenal fat sac to alleviate her symptoms. After surgery, gene sequencing was performed to determine the possible cause of the condition. However, five months after discharge, the patient was hospitalized again because of retroperitoneal and peritoneal multiple metastases. Nine months after surgery, the patient died. This case is likely to aid in furthering our understanding of PHNEC to improve the future diagnosis and treatment of this disease. Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9334775/ /pubmed/35910478 http://dx.doi.org/10.3389/fsurg.2022.920276 Text en © 2022 Huang, Lan, Chen, Zhang, Wang, Zhu, Xu, Zhang, Lu, Guo and Wen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Huang, Keyu
Lan, Zhujing
Chen, Weitao
Zhang, Jianyong
Wang, Jilong
Zhu, Hai
Xu, Banghao
Zhang, Ling
Lu, Tingting
Guo, Ya
Wen, Zhang
Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title_full Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title_fullStr Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title_full_unstemmed Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title_short Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature
title_sort hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: case report and review of the literature
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334775/
https://www.ncbi.nlm.nih.gov/pubmed/35910478
http://dx.doi.org/10.3389/fsurg.2022.920276
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