Electrochemical biosensors for detection of SARS-CoV-2

Pathogen detection is an essential application of electrochemical biosensors. Through the integration of selective biorecognition elements with sensitive transducers, electrochemical biosensors have enabled the rapid, sensitive, and selective detection of viruses. While various studies have achieved impressive detection limits, in some cases a single virus or tens to hundreds of viral RNA molecules, the developed approaches for electrochemical detection of virus particles significantly vary in regard to device and measurement approach, such as the electrode, biorecognition element, electrochemical method utilized for transduction of target binding, and measurement format (e.g., sample collection, preparation, and handling protocols). Thus, the reagents, materials, and measurement approach must be carefully considered to accurately assess the utility and time-to-results (TTR) for a given electrochemical biosensor-based assay for pathogen detection in a pandemic setting.