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Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies

TSH receptor (TSHR) antibodies are the cause of Graves’ disease and may also be found in patients with Hashimoto’s thyroiditis. They come in at least three varieties: thyroid stimulating, thyroid blocking and neutral. The measurement of TSH receptor antibodies in Graves’ disease and Hashimoto’s thyr...

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Autores principales: Davies, Terry F., Morshed, Syed A., Mezei, Mihaly, Latif, Rauf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335193/
https://www.ncbi.nlm.nih.gov/pubmed/35909553
http://dx.doi.org/10.3389/fendo.2022.943459
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author Davies, Terry F.
Morshed, Syed A.
Mezei, Mihaly
Latif, Rauf
author_facet Davies, Terry F.
Morshed, Syed A.
Mezei, Mihaly
Latif, Rauf
author_sort Davies, Terry F.
collection PubMed
description TSH receptor (TSHR) antibodies are the cause of Graves’ disease and may also be found in patients with Hashimoto’s thyroiditis. They come in at least three varieties: thyroid stimulating, thyroid blocking and neutral. The measurement of TSH receptor antibodies in Graves’ disease and Hashimoto’s thyroiditis is a common clinical activity and can be useful in diagnosis and prognosis. We show that it is not possible to detect the blocking variety of TSHR antibody in patients with Graves’ disease because the stimulating antibody may overwhelm the measurement of blocking in the bioassays available for their measurement and may blind the valid interpretation of the results. To help explain this in more detail we show a series of studies with monoclonal TSHR antibodies which support this conclusion.
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spelling pubmed-93351932022-07-30 Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies Davies, Terry F. Morshed, Syed A. Mezei, Mihaly Latif, Rauf Front Endocrinol (Lausanne) Endocrinology TSH receptor (TSHR) antibodies are the cause of Graves’ disease and may also be found in patients with Hashimoto’s thyroiditis. They come in at least three varieties: thyroid stimulating, thyroid blocking and neutral. The measurement of TSH receptor antibodies in Graves’ disease and Hashimoto’s thyroiditis is a common clinical activity and can be useful in diagnosis and prognosis. We show that it is not possible to detect the blocking variety of TSHR antibody in patients with Graves’ disease because the stimulating antibody may overwhelm the measurement of blocking in the bioassays available for their measurement and may blind the valid interpretation of the results. To help explain this in more detail we show a series of studies with monoclonal TSHR antibodies which support this conclusion. Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9335193/ /pubmed/35909553 http://dx.doi.org/10.3389/fendo.2022.943459 Text en Copyright © 2022 Davies, Morshed, Mezei and Latif https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Davies, Terry F.
Morshed, Syed A.
Mezei, Mihaly
Latif, Rauf
Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title_full Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title_fullStr Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title_full_unstemmed Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title_short Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
title_sort brief report - monoclonal antibodies illustrate the difficulties in measuring blocking tsh receptor antibodies
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335193/
https://www.ncbi.nlm.nih.gov/pubmed/35909553
http://dx.doi.org/10.3389/fendo.2022.943459
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