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Effects of polymorphisms in the MTHFR gene on 5-FU hematological toxicity and efficacy in Thai colorectal cancer patients

BACKGROUND: The two common methylenetetrahydrofolate reductase (MTHFR) polymorphisms 677G>A and 1298A>C may have been affecting 5-FU toxicity in cancer patients for decades. Drug efficacy has also been shown by previous studies to be affected. In this study, we investigated the effects of thes...

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Detalles Bibliográficos
Autores principales:	Atasilp, Chalirmporn, Lenavat, Rinradee, Vanwong, Natchaya, Chansriwong, Phichai, Sirachainan, Ekaphop, Reungwetwattana, Thanyanan, Jinda, Pimonpan, Aiempradit, Somthawin, Sirilerttrakul, Suwannee, Chamnanphon, Monpat, Puangpetch, Apichaya, Sankuntaw, Nipaporn, Satapornpong, Patompong, Sukasem, Chonlaphat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335196/ https://www.ncbi.nlm.nih.gov/pubmed/35912215 http://dx.doi.org/10.3389/fonc.2022.916650

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