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Transient and durable T cell reactivity after COVID-19

This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides span...

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Detalles Bibliográficos
Autores principales: Martner, Anna, Grauers Wiktorin, Hanna, Törnell, Andreas, Ringlander, Johan, Arabpour, Mohammad, Lindh, Magnus, Lagging, Martin, Nilsson, Staffan, Hellstrand, Kristoffer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335198/
https://www.ncbi.nlm.nih.gov/pubmed/35858456
http://dx.doi.org/10.1073/pnas.2203659119
Descripción
Sumario:This study analyzed whole blood samples (n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syndrome coronavirus 2–derived antigens. Multimeric peptides spanning the entire nucleocapsid protein triggered strikingly synchronous formation of interleukin (IL)-4, IL-12, IL-13, and IL-17 ex vivo until ∼70 d after confirmed infection, whereafter this reactivity was no longer inducible. In contrast, levels of nucleocapsid-induced IL-2 and interferon-γ remained stable and highly correlated at 3 to 21 mo after infection. Similar cytokine dynamics were observed in unvaccinated, convalescent patients using whole-blood samples stimulated with peptides spanning the N-terminal portion of the spike 1 protein. These results unravel two phases of T cell reactivity following natural COVID-19: an early, synchronous response indicating transient presence of multipolar, antigen-specific T helper (T(H)) cells followed by an equally synchronous and durable T(H)1-like reactivity reflecting long-lasting T cell memory.