Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states

Alphaviruses can cause severe human arthritis and encephalitis. During virus infection, structural changes of viral glycoproteins in the acidified endosome trigger virus–host membrane fusion for delivery of the capsid core and RNA genome into the cytosol to initiate virus translation and replication...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Liang, Klose, Thomas, Sun, Chengqun, Kim, Arthur S., Buda, Geeta, Rossmann, Michael G., Diamond, Michael S., Klimstra, William B., Kuhn, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335222/
https://www.ncbi.nlm.nih.gov/pubmed/35867819
http://dx.doi.org/10.1073/pnas.2114119119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335222/
https://www.ncbi.nlm.nih.gov/pubmed/35867819
http://dx.doi.org/10.1073/pnas.2114119119

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