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Cryo-EM structures of alphavirus conformational intermediates in low pH–triggered prefusion states
Alphaviruses can cause severe human arthritis and encephalitis. During virus infection, structural changes of viral glycoproteins in the acidified endosome trigger virus–host membrane fusion for delivery of the capsid core and RNA genome into the cytosol to initiate virus translation and replication...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335222/ https://www.ncbi.nlm.nih.gov/pubmed/35867819 http://dx.doi.org/10.1073/pnas.2114119119 |