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Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

Folate metabolism plays an essential role in tumor development. Various cancers display therapeutic response to reagents targeting key enzymes of the folate cycle, but obtain chemoresistance later. Therefore, novel targets in folate metabolism are highly demanded. Methylenetetrahydrofolate dehydroge...

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Detalles Bibliográficos
Autores principales:	Zhang, Fan, Wang, Di, Li, Jintao, Su, Ying, Liu, Suling, Lei, Qun-Ying, Yin, Miao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335224/ https://www.ncbi.nlm.nih.gov/pubmed/35349697 http://dx.doi.org/10.1093/jmcb/mjac020

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