Genome-scale modeling drives 70-fold improvement of intracellular heme production in Saccharomyces cerevisiae

Heme is an oxygen carrier and a cofactor of both industrial enzymes and food additives. The intracellular level of free heme is low, which limits the synthesis of heme proteins. Therefore, increasing heme synthesis allows an increased production of heme proteins. Using the genome-scale metabolic mod...

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Detalles Bibliográficos
Autores principales: Ishchuk, Olena P., Domenzain, Iván, Sánchez, Benjamín J., Muñiz-Paredes, Facundo, Martínez, José L., Nielsen, Jens, Petranovic, Dina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335255/
https://www.ncbi.nlm.nih.gov/pubmed/35858410
http://dx.doi.org/10.1073/pnas.2108245119

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