Toll-Like Receptor 4 Signaling in the Trabecular Meshwork

Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is sig...

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Autores principales: Mzyk, Philip, Hernandez, Humberto, Le, Thanh, Ramirez, Jose Ricardo, McDowell, Colleen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335276/
https://www.ncbi.nlm.nih.gov/pubmed/35912101
http://dx.doi.org/10.3389/fcell.2022.936115
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author Mzyk, Philip
Hernandez, Humberto
Le, Thanh
Ramirez, Jose Ricardo
McDowell, Colleen M.
author_facet Mzyk, Philip
Hernandez, Humberto
Le, Thanh
Ramirez, Jose Ricardo
McDowell, Colleen M.
author_sort Mzyk, Philip
collection PubMed
description Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure
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spelling pubmed-93352762022-07-30 Toll-Like Receptor 4 Signaling in the Trabecular Meshwork Mzyk, Philip Hernandez, Humberto Le, Thanh Ramirez, Jose Ricardo McDowell, Colleen M. Front Cell Dev Biol Cell and Developmental Biology Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has implicated Toll-like receptor 4 (TLR4) and it is signaling pathway in augmenting the effects of transforming growth factor beta-2 (TGFβ2) and downstream extracellular matrix production. In this review, we examine the role of TLR4 signaling in the trabecular meshwork and the interplay between endogenous activators of TLR4 (damage-associated molecular patterns (DAMPs)), extracellular matrix (ECM), and the effect on intraocular pressure Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9335276/ /pubmed/35912101 http://dx.doi.org/10.3389/fcell.2022.936115 Text en Copyright © 2022 Mzyk, Hernandez, Le, Ramirez and McDowell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Mzyk, Philip
Hernandez, Humberto
Le, Thanh
Ramirez, Jose Ricardo
McDowell, Colleen M.
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title_full Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title_fullStr Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title_full_unstemmed Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title_short Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
title_sort toll-like receptor 4 signaling in the trabecular meshwork
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335276/
https://www.ncbi.nlm.nih.gov/pubmed/35912101
http://dx.doi.org/10.3389/fcell.2022.936115
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