Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine

Structures trapping a variety of functional and conformational states of HIV-1 reverse transcriptase (RT) have been determined by X-ray crystallography. These structures have played important roles in explaining the mechanisms of catalysis, inhibition, and drug resistance and in driving drug design....

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Detalles Bibliográficos
Autores principales: Singh, Abhimanyu K., De Wijngaert, Brent, Bijnens, Marc, Uyttersprot, Kris, Nguyen, Hoai, Martinez, Sergio E., Schols, Dominique, Herdewijn, Piet, Pannecouque, Christophe, Arnold, Eddy, Das, Kalyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335299/
https://www.ncbi.nlm.nih.gov/pubmed/35858448
http://dx.doi.org/10.1073/pnas.2203660119

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