Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression

Autosomal dominant polycystic kidney disease (ADPKD) affects more than 500,000 individuals in the United States alone. In most cases, ADPKD is caused by a loss-of-function mutation in the PKD1 gene, which encodes polycystin-1 (PC1). Previous studies reported that PC1 interacts with atypical protein...

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Detalles Bibliográficos
Autores principales: Akbari, Masaw, West, Jonathan D., Doerr, Nicholas, Kipp, Kevin R., Marhamati, Neda, Vuong, Sabrina, Wang, Yidi, Rinschen, Markus M., Talbot, Jeffrey J., Wessely, Oliver, Weimbs, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335328/
https://www.ncbi.nlm.nih.gov/pubmed/35867829
http://dx.doi.org/10.1073/pnas.2121267119

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