Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

Oncogenic mutations within the epidermal growth factor receptor (EGFR) are found in 15 to 30% of all non–small-cell lung carcinomas. The term exon 19 deletion (ex19del) is collectively used to refer to more than 20 distinct genomic alterations within exon 19 that comprise the most common EGFR mutati...

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Detalles Bibliográficos
Autores principales: Brown, Benjamin P., Zhang, Yun-Kai, Kim, Soyeon, Finneran, Patrick, Yan, Yingjun, Du, Zhenfang, Kim, Jiyoon, Hartzler, Abigail Leigh, LeNoue-Newton, Michele L., Smith, Adam W., Meiler, Jens, Lovly, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335329/
https://www.ncbi.nlm.nih.gov/pubmed/35867821
http://dx.doi.org/10.1073/pnas.2206588119

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