Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation

During translation initiation, eIF4G1 dynamically interacts with eIF4E and eIF1. While the role of eIF4E–eIF4G1 is well established, the regulatory functions of eIF4G1–eIF1 are poorly understood. Here, we report the identification of the eIF4G1–eIF1 inhibitors i14G1-10 and i14G1-12. i14G1s directly...

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Detalles Bibliográficos
Autores principales: Sehrawat, Urmila, Haimov, Ora, Weiss, Benjamin, Tamarkin-Ben Harush, Ana, Ashkenazi, Shaked, Plotnikov, Alexander, Noiman, Tzahi, Leshkowitz, Dena, Stelzer, Gil, Dikstein, Rivka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335335/
https://www.ncbi.nlm.nih.gov/pubmed/35857873
http://dx.doi.org/10.1073/pnas.2120339119

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