Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions

NF-κB–mediated endothelial activation drives leukocyte recruitment and atherosclerosis, in part through adhesion molecules Icam1 and Vcam1. The endothelium is primed for cytokine activation of NF-κB by exposure to low and disturbed blood flow (LDF)but the molecular underpinnings are not fully unders...

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Detalles Bibliográficos
Autores principales: Hensel, Jessica A., Nicholas, Sarah-Anne E., Kimble, Amy L., Nagpal, Arjun S., Omar, Omar M. F., Tyburski, Jordan D., Jellison, Evan R., Ménoret, Antoine, Ozawa, Manabu, Rodriguez-Oquendo, Annabelle, Vella, Anthony T., Murphy, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335344/
https://www.ncbi.nlm.nih.gov/pubmed/35858420
http://dx.doi.org/10.1073/pnas.2122227119

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