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Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021

OBJECTIVES: To estimate the proportion of the population infected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Canada through April 2021, 16 months into the coronavirus disease 2019 (COVID-19) pandemic and 4 months after COVID-19 vaccines became available. METHODS: Publication...

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Autores principales: Major, Maria, Majowicz, Shannon E., Oremus, Mark, Jimenez, Laura Juliana, Angulo, Frederick J., Horton, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335354/
https://www.ncbi.nlm.nih.gov/pubmed/35919829
http://dx.doi.org/10.1016/j.ijregi.2022.07.010
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author Major, Maria
Majowicz, Shannon E.
Oremus, Mark
Jimenez, Laura Juliana
Angulo, Frederick J.
Horton, Susan
author_facet Major, Maria
Majowicz, Shannon E.
Oremus, Mark
Jimenez, Laura Juliana
Angulo, Frederick J.
Horton, Susan
author_sort Major, Maria
collection PubMed
description OBJECTIVES: To estimate the proportion of the population infected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Canada through April 2021, 16 months into the coronavirus disease 2019 (COVID-19) pandemic and 4 months after COVID-19 vaccines became available. METHODS: Publication databases, preprint servers, public health databases and the grey literature were searched for seroprevalence surveys conducted in Canada from 1 November 2019 to 10 July 2021. Studies were assessed for bias using the Joanna Briggs Checklist. Numbers of infections derived from seroprevalence estimates were compared with reported cases to estimate under-ascertainment ratios. RESULTS: In total, 12 serosurveys with 210,321 participants were identified. Three (25%) serosurveys were conducted at national level, one (8.3%) was conducted at provincial level, and eight (66.7%) were conducted at local level. All 12 serosurveys had moderate or high risk of bias. The proportion of the population infected by April 2021 was low (2.6%). The proportion of the population infected was higher in surveys of residents of long-term care facilities (43.0–86%), workers at long-term care facilities (22.4–32.4%), and workers in healthcare institutions (1.4–14%). CONCLUSIONS: As of April 2021, the proportion of the population infected by SARS-CoV-2 was low in the overall population of Canada, but was high in healthcare facilities, particularly long-term care facilities, supporting the need for vaccines.
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spelling pubmed-93353542022-07-29 Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021 Major, Maria Majowicz, Shannon E. Oremus, Mark Jimenez, Laura Juliana Angulo, Frederick J. Horton, Susan IJID Reg Review OBJECTIVES: To estimate the proportion of the population infected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Canada through April 2021, 16 months into the coronavirus disease 2019 (COVID-19) pandemic and 4 months after COVID-19 vaccines became available. METHODS: Publication databases, preprint servers, public health databases and the grey literature were searched for seroprevalence surveys conducted in Canada from 1 November 2019 to 10 July 2021. Studies were assessed for bias using the Joanna Briggs Checklist. Numbers of infections derived from seroprevalence estimates were compared with reported cases to estimate under-ascertainment ratios. RESULTS: In total, 12 serosurveys with 210,321 participants were identified. Three (25%) serosurveys were conducted at national level, one (8.3%) was conducted at provincial level, and eight (66.7%) were conducted at local level. All 12 serosurveys had moderate or high risk of bias. The proportion of the population infected by April 2021 was low (2.6%). The proportion of the population infected was higher in surveys of residents of long-term care facilities (43.0–86%), workers at long-term care facilities (22.4–32.4%), and workers in healthcare institutions (1.4–14%). CONCLUSIONS: As of April 2021, the proportion of the population infected by SARS-CoV-2 was low in the overall population of Canada, but was high in healthcare facilities, particularly long-term care facilities, supporting the need for vaccines. Elsevier 2022-07-29 /pmc/articles/PMC9335354/ /pubmed/35919829 http://dx.doi.org/10.1016/j.ijregi.2022.07.010 Text en © 2022 Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Major, Maria
Majowicz, Shannon E.
Oremus, Mark
Jimenez, Laura Juliana
Angulo, Frederick J.
Horton, Susan
Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title_full Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title_fullStr Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title_full_unstemmed Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title_short Systematic literature review of SARS-CoV-2 seroprevalence surveys in Canada through April 2021
title_sort systematic literature review of sars-cov-2 seroprevalence surveys in canada through april 2021
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335354/
https://www.ncbi.nlm.nih.gov/pubmed/35919829
http://dx.doi.org/10.1016/j.ijregi.2022.07.010
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