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The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders

Animal models have been used to model human diseases, and among them, small fishes have been highlighted for their usefulness in various ways, such as the low cost of maintenance, ease of genetic modification, small size for easy handling, and strength in imaging studies due to their relative transp...

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Autores principales: Dohi, Eisuke, Matsui, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335361/
https://www.ncbi.nlm.nih.gov/pubmed/35910227
http://dx.doi.org/10.3389/fgene.2022.928597
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author Dohi, Eisuke
Matsui, Hideaki
author_facet Dohi, Eisuke
Matsui, Hideaki
author_sort Dohi, Eisuke
collection PubMed
description Animal models have been used to model human diseases, and among them, small fishes have been highlighted for their usefulness in various ways, such as the low cost of maintenance, ease of genetic modification, small size for easy handling, and strength in imaging studies due to their relative transparency. Recently, the use of turquoise killifish, Nothobranchius furzeri, which is known to exhibit various aging phenotypes in a short period, has attracted attention in research on aging and age-related diseases. However, when using animal models, it is important to keep their genetic background and interspecies differences in mind for translating them into human diseases. In this article, we obtained the gene symbols of protein-coding genes of turquoise killifish, medaka, zebrafish, and humans from NCBI datasets and extracted common shared genes among four species to explore the potential of interspecies translational research and to apply small fish models for human age-related disorders. Common shared protein-coding genes were analyzed with the Reactome Pathway Database to determine the coverage of these genes in each pathway in humans. We applied common shared genes to the Orphanet database to establish a list of human diseases that contain common shared genes among the four species. As examples, the senescence-related pathways and some pathways of human age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, nonalcoholic fatty liver disease, progeria, hepatocellular carcinoma, and renal cell carcinoma, were extracted from the curated pathway and disease list to discuss the further utility of fish models for human age-related disorders.
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spelling pubmed-93353612022-07-30 The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders Dohi, Eisuke Matsui, Hideaki Front Genet Genetics Animal models have been used to model human diseases, and among them, small fishes have been highlighted for their usefulness in various ways, such as the low cost of maintenance, ease of genetic modification, small size for easy handling, and strength in imaging studies due to their relative transparency. Recently, the use of turquoise killifish, Nothobranchius furzeri, which is known to exhibit various aging phenotypes in a short period, has attracted attention in research on aging and age-related diseases. However, when using animal models, it is important to keep their genetic background and interspecies differences in mind for translating them into human diseases. In this article, we obtained the gene symbols of protein-coding genes of turquoise killifish, medaka, zebrafish, and humans from NCBI datasets and extracted common shared genes among four species to explore the potential of interspecies translational research and to apply small fish models for human age-related disorders. Common shared protein-coding genes were analyzed with the Reactome Pathway Database to determine the coverage of these genes in each pathway in humans. We applied common shared genes to the Orphanet database to establish a list of human diseases that contain common shared genes among the four species. As examples, the senescence-related pathways and some pathways of human age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, nonalcoholic fatty liver disease, progeria, hepatocellular carcinoma, and renal cell carcinoma, were extracted from the curated pathway and disease list to discuss the further utility of fish models for human age-related disorders. Frontiers Media S.A. 2022-07-15 /pmc/articles/PMC9335361/ /pubmed/35910227 http://dx.doi.org/10.3389/fgene.2022.928597 Text en Copyright © 2022 Dohi and Matsui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Dohi, Eisuke
Matsui, Hideaki
The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title_full The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title_fullStr The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title_full_unstemmed The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title_short The Utility of Small Fishes for the Genetic Study of Human Age-Related Disorders
title_sort utility of small fishes for the genetic study of human age-related disorders
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335361/
https://www.ncbi.nlm.nih.gov/pubmed/35910227
http://dx.doi.org/10.3389/fgene.2022.928597
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