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On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study

[Image: see text] Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/co...

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Autores principales: Lacerda, Sara, Zhang, Wuyuan, T. M. de Rosales, Rafael, Da Silva, Isidro, Sobilo, Julien, Lerondel, Stéphanie, Tóth, Éva, Djanashvili, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335405/
https://www.ncbi.nlm.nih.gov/pubmed/35830285
http://dx.doi.org/10.1021/acsami.2c03841
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author Lacerda, Sara
Zhang, Wuyuan
T. M. de Rosales, Rafael
Da Silva, Isidro
Sobilo, Julien
Lerondel, Stéphanie
Tóth, Éva
Djanashvili, Kristina
author_facet Lacerda, Sara
Zhang, Wuyuan
T. M. de Rosales, Rafael
Da Silva, Isidro
Sobilo, Julien
Lerondel, Stéphanie
Tóth, Éva
Djanashvili, Kristina
author_sort Lacerda, Sara
collection PubMed
description [Image: see text] Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (Gd(III)) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 ((89)Zr). Thereby, exploiting (89)Zr-chloride resulted in a slightly higher radiolabeling in the inner cavities compared to the commonly used (89)Zr-oxalate, which apparently remained on the surface of LTL. Intravenous injection of PEGylated (89)Zr/Gd(III)-LTL in healthy mice allowed for PET–computed tomography evaluation, revealing initial lung uptake followed by gradual migration of LTL to the liver and spleen. Ex vivo biodistribution confirmed the in vivo stability and integrity of the proposed multimodal probe by demonstrating the original metal/Si ratio being preserved in the organs. These findings reveal beneficial biological behavior of the nanozeolite LTL and hence open the door for follow-up theranostic studies by exploiting the immense variety of metal-based radioisotopes.
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spelling pubmed-93354052022-07-30 On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study Lacerda, Sara Zhang, Wuyuan T. M. de Rosales, Rafael Da Silva, Isidro Sobilo, Julien Lerondel, Stéphanie Tóth, Éva Djanashvili, Kristina ACS Appl Mater Interfaces [Image: see text] Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (Gd(III)) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 ((89)Zr). Thereby, exploiting (89)Zr-chloride resulted in a slightly higher radiolabeling in the inner cavities compared to the commonly used (89)Zr-oxalate, which apparently remained on the surface of LTL. Intravenous injection of PEGylated (89)Zr/Gd(III)-LTL in healthy mice allowed for PET–computed tomography evaluation, revealing initial lung uptake followed by gradual migration of LTL to the liver and spleen. Ex vivo biodistribution confirmed the in vivo stability and integrity of the proposed multimodal probe by demonstrating the original metal/Si ratio being preserved in the organs. These findings reveal beneficial biological behavior of the nanozeolite LTL and hence open the door for follow-up theranostic studies by exploiting the immense variety of metal-based radioisotopes. American Chemical Society 2022-07-13 2022-07-27 /pmc/articles/PMC9335405/ /pubmed/35830285 http://dx.doi.org/10.1021/acsami.2c03841 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Lacerda, Sara
Zhang, Wuyuan
T. M. de Rosales, Rafael
Da Silva, Isidro
Sobilo, Julien
Lerondel, Stéphanie
Tóth, Éva
Djanashvili, Kristina
On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title_full On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title_fullStr On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title_full_unstemmed On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title_short On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study
title_sort on the versatility of nanozeolite linde type l for biomedical applications: zirconium-89 radiolabeling and in vivo positron emission tomography study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335405/
https://www.ncbi.nlm.nih.gov/pubmed/35830285
http://dx.doi.org/10.1021/acsami.2c03841
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