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N(1)-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
In vitro transcribed synthetic messenger RNAs (mRNAs) represent a novel therapeutic modality. To overcome the inherent immunogenicity, as well as to increase the therapeutic efficacy of the molecules, uridine analogs—such as pseudouridine (Ψ) and N(1)-methyl-pseudouridine (m1Ψ), are incorporated in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335462/ https://www.ncbi.nlm.nih.gov/pubmed/35906281 http://dx.doi.org/10.1038/s41598-022-17249-1 |