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Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations
BACKGROUND: Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are recognized by host T cells through a complex formation of the T cell receptor (TCR) with pMHC. In the present study, we report on c...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335952/ https://www.ncbi.nlm.nih.gov/pubmed/35902791 http://dx.doi.org/10.1186/s12865-022-00510-7 |