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Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis

BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associat...

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Autores principales: Suzuki, Takahito, Karayama, Masato, Inoue, Yusuke, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Inui, Naoki, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335968/
https://www.ncbi.nlm.nih.gov/pubmed/35902843
http://dx.doi.org/10.1186/s12890-022-02084-x
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author Suzuki, Takahito
Karayama, Masato
Inoue, Yusuke
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Fujisawa, Tomoyuki
Enomoto, Noriyuki
Nakamura, Yutaro
Inui, Naoki
Suda, Takafumi
author_facet Suzuki, Takahito
Karayama, Masato
Inoue, Yusuke
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Fujisawa, Tomoyuki
Enomoto, Noriyuki
Nakamura, Yutaro
Inui, Naoki
Suda, Takafumi
author_sort Suzuki, Takahito
collection PubMed
description BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. RESULTS: The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. CONCLUSIONS: Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02084-x.
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spelling pubmed-93359682022-07-30 Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis Suzuki, Takahito Karayama, Masato Inoue, Yusuke Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Fujisawa, Tomoyuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Suda, Takafumi BMC Pulm Med Research BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. RESULTS: The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. CONCLUSIONS: Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02084-x. BioMed Central 2022-07-28 /pmc/articles/PMC9335968/ /pubmed/35902843 http://dx.doi.org/10.1186/s12890-022-02084-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Suzuki, Takahito
Karayama, Masato
Inoue, Yusuke
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Fujisawa, Tomoyuki
Enomoto, Noriyuki
Nakamura, Yutaro
Inui, Naoki
Suda, Takafumi
Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title_full Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title_fullStr Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title_full_unstemmed Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title_short Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
title_sort associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335968/
https://www.ncbi.nlm.nih.gov/pubmed/35902843
http://dx.doi.org/10.1186/s12890-022-02084-x
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