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Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis
BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335968/ https://www.ncbi.nlm.nih.gov/pubmed/35902843 http://dx.doi.org/10.1186/s12890-022-02084-x |
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author | Suzuki, Takahito Karayama, Masato Inoue, Yusuke Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Fujisawa, Tomoyuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Suda, Takafumi |
author_facet | Suzuki, Takahito Karayama, Masato Inoue, Yusuke Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Fujisawa, Tomoyuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Suda, Takafumi |
author_sort | Suzuki, Takahito |
collection | PubMed |
description | BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. RESULTS: The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. CONCLUSIONS: Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02084-x. |
format | Online Article Text |
id | pubmed-9335968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93359682022-07-30 Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis Suzuki, Takahito Karayama, Masato Inoue, Yusuke Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Fujisawa, Tomoyuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Suda, Takafumi BMC Pulm Med Research BACKGROUND: Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. METHODS: The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis were also evaluated. RESULTS: The patients with sarcoidosis had significantly lower levels of n-3 poly-unsaturated fatty acids (PUFAs) (p < 0.001) and n-6 PUFAs (p < 0.001) than the healthy controls. However, there were no significant differences in the levels of saturated fatty acids (SFAs) and mono-unsaturated fatty acids (MUFAs) between the two groups. On multivariate logistic analysis, lower levels of n-3 PUFAs, n-6 PUFAs, and n-3/n-6 ratio were predictive of sarcoidosis. Among the patients with sarcoidosis, those with multiple organ involvement had significantly lower levels of n-3 PUFAs and n-3/n-6 ratio than those with single organ involvement. There were no significant differences in the levels of n-6 PUFAs, SFAs, and MUFAs between the patients with multiple and single organ involvement. On multivariate logistic analysis, lower levels of SFAs and n-3/n-6 ratio were predictive of multiple organ involvement. The levels of LCFAs had no significant association with radiographic stage or spontaneous remission. CONCLUSIONS: Assessment of LCFA profiles may be useful for the diagnosis of sarcoidosis and evaluation of the disease activity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-022-02084-x. BioMed Central 2022-07-28 /pmc/articles/PMC9335968/ /pubmed/35902843 http://dx.doi.org/10.1186/s12890-022-02084-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Suzuki, Takahito Karayama, Masato Inoue, Yusuke Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Fujisawa, Tomoyuki Enomoto, Noriyuki Nakamura, Yutaro Inui, Naoki Suda, Takafumi Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title_full | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title_fullStr | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title_full_unstemmed | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title_short | Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
title_sort | associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335968/ https://www.ncbi.nlm.nih.gov/pubmed/35902843 http://dx.doi.org/10.1186/s12890-022-02084-x |
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