Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1

BACKGROUND: Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by a polyglutamine expansion in the ataxin-1 protein. The pathogenic mechanism resulting in SCA1 is still unclear. Protein–protein interactions affect the function and stability of ataxin-1. METHODS: Wild-type and...

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Detalles Bibliográficos
Autores principales: Chen, Jiu-Ming, Chen, Shi-Kai, Jin, Pei-Pei, Sun, Shun-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335979/
https://www.ncbi.nlm.nih.gov/pubmed/35906672
http://dx.doi.org/10.1186/s40246-022-00404-0

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