Oncogenic roles of the lncRNA LINC00460 in human cancers

Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation an...

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Autores principales: Su, Min, Tang, Jinming, Yang, Desong, Wu, Zhining, Liao, Qianjin, Wang, Hui, Xiao, Yuhang, Wang, Wenxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336008/
https://www.ncbi.nlm.nih.gov/pubmed/35906593
http://dx.doi.org/10.1186/s12935-022-02655-2
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author Su, Min
Tang, Jinming
Yang, Desong
Wu, Zhining
Liao, Qianjin
Wang, Hui
Xiao, Yuhang
Wang, Wenxiang
author_facet Su, Min
Tang, Jinming
Yang, Desong
Wu, Zhining
Liao, Qianjin
Wang, Hui
Xiao, Yuhang
Wang, Wenxiang
author_sort Su, Min
collection PubMed
description Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation and progression. Long intergenic non-protein coding RNA 460 (LINC00460), a novel cancer-related lncRNA, exhibits abnormal expression and oncogenic function in multiple cancers, and positively correlates with poor clinical characteristics of cancer patients. LINC00460 has also been shown to be a promising biomarker for diagnosis as well as prognostic evaluation in cancer patients. In this review, we briefly summarized recent knowledge on the expression, functional roles, molecular mechanisms, and diagnostic and prognostic values of LINC00460 in human malignancies.
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spelling pubmed-93360082022-07-30 Oncogenic roles of the lncRNA LINC00460 in human cancers Su, Min Tang, Jinming Yang, Desong Wu, Zhining Liao, Qianjin Wang, Hui Xiao, Yuhang Wang, Wenxiang Cancer Cell Int Review Long noncoding RNAs (lncRNAs) represent an important group of endogenous RNAs with limit protein-encoding capability, with a length of more than 200 nucleotides. Emerging evidence have demonstrated that lncRNAs are greatly involved in multiple cancers by playing critical roles in tumor initiation and progression. Long intergenic non-protein coding RNA 460 (LINC00460), a novel cancer-related lncRNA, exhibits abnormal expression and oncogenic function in multiple cancers, and positively correlates with poor clinical characteristics of cancer patients. LINC00460 has also been shown to be a promising biomarker for diagnosis as well as prognostic evaluation in cancer patients. In this review, we briefly summarized recent knowledge on the expression, functional roles, molecular mechanisms, and diagnostic and prognostic values of LINC00460 in human malignancies. BioMed Central 2022-07-29 /pmc/articles/PMC9336008/ /pubmed/35906593 http://dx.doi.org/10.1186/s12935-022-02655-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Su, Min
Tang, Jinming
Yang, Desong
Wu, Zhining
Liao, Qianjin
Wang, Hui
Xiao, Yuhang
Wang, Wenxiang
Oncogenic roles of the lncRNA LINC00460 in human cancers
title Oncogenic roles of the lncRNA LINC00460 in human cancers
title_full Oncogenic roles of the lncRNA LINC00460 in human cancers
title_fullStr Oncogenic roles of the lncRNA LINC00460 in human cancers
title_full_unstemmed Oncogenic roles of the lncRNA LINC00460 in human cancers
title_short Oncogenic roles of the lncRNA LINC00460 in human cancers
title_sort oncogenic roles of the lncrna linc00460 in human cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336008/
https://www.ncbi.nlm.nih.gov/pubmed/35906593
http://dx.doi.org/10.1186/s12935-022-02655-2
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