Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

BACKGROUND: Interferon gamma (IFNγ) is a pro-inflammatory cytokine that directly activates the JAK/STAT pathway. However, the temporal dynamics of chromatin remodeling and transcriptional activation initiated by IFNγ have not been systematically profiled in an unbiased manner. Herein, we integrated...

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Detalles Bibliográficos
Autores principales: Hogg, Simon J., Motorna, Olga, Kearney, Conor J., Derrick, Emily B., House, Imran G., Todorovski, Izabela, Kelly, Madison J., Zethoven, Magnus, Bromberg, Kenneth D., Lai, Albert, Beavis, Paul A., Shortt, Jake, Johnstone, Ricky W., Vervoort, Stephin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336046/
https://www.ncbi.nlm.nih.gov/pubmed/35902886
http://dx.doi.org/10.1186/s13148-022-01316-5

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