A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML

BACKGROUND: Myeloid and lymphoid malignancies associated with chimeric FGFR1 kinases are the hallmark of stem cell leukemia and lymphoma syndrome (SCLL). In all cases, FGFR1 kinase is constitutively phosphoactivated as a result of chromosome translocations, which lead to acquisition of dimerization...

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Detalles Bibliográficos
Autores principales: Cai, Baohuan, Liu, Yun, Chong, Yating, Mori, Stephanie Fay, Matsunaga, Atsuko, Zhang, Hualei, Fang, Xuexiu, Chang, Chang-Sheng, Cowell, John K., Hu, Tianxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336057/
https://www.ncbi.nlm.nih.gov/pubmed/35906694
http://dx.doi.org/10.1186/s12943-022-01628-3

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